41 Result(s)

Article

Reactions of aminoguanidine and guanidine with 3- and 5-formyl-4-arylaminopyridones

Amidinohydrazones were prepared by the condensation of 4-arylamino-2-oxo-5-formyl-1,2-dihydropyridine-3-carbonitriles and 4-arylamino-2-oxo-1,2-dihydropyridine-3-carbaldehydes with aminoguanidinium carbonate w...

M. I. Medvedeva, N. Z. Tugusheva, L. M. Alekseeva… in Russian Chemical Bulletin (2010)

Article

1,3,5-Triazinenitrolic acids. Synthesis and NO-releasing properties

Reactions of salts of 1,3,5-triazine dinitromethyl derivatives with nitrogen dioxide that result mainly in 1,3,5-triazinenitrolic acids are investigated. The behavior of nitrolic acid in electroreduction at a ...

V. V. Bakharev, A. A. Gidaspov, E. V. Peresedova, V. G. Granik… in Russian Chemical Bulletin (2009)

Article

Acyl migration during alkylation of acetoxyurea derivatives

The alkylation of N-acetoxy-N-(benzofuran-2-yl)urea is performed in the presence of sodium hydride. This process is accompanied by the migration of the acetyl group with the formation of O-acetylisourea. The k...

O. A. Onuchina, S. A. Zaitsev, V. I. Levina… in Pharmaceutical Chemistry Journal (2007)

Article

Kinetics of hydrolysis of five-membered C-nitroheterocycles: pyrazole, imidazole, 1,2,4-triazole, and isoxazole derivatives

Alkaline hydrolysis of mono-and dinitro derivatives of five-membered heterocycles, viz., pyrazole, imidazole, 1,2,4-triazole, and isoxazole, is accompanied by the elimination of the nitro group in the form of a n...

L. A. Trukhacheva, V. I. Levina, N. B. Grigor’ev… in Russian Chemical Bulletin (2005)

Article

4-(N,N-Dialkylthiocarbamoylthio)-5-nitropyrimidines as new potential nitric oxide donors

On heating at pH 6.86, 4-(N,N-dialkylthiocarbamoylthio)-5-nitropyrimidines are transformed into dithiolopyrimidines, which are either oxidized to bis(4-dialkylthiocarbamoylpyrimidin-5-yl) disulfides or converted ...

O. B. Ryabova, E. Yu. Khmel’nitskaya, V. A. Makarov… in Russian Chemical Bulletin (2005)

Article

Comparison of reactivities of 1- and 4-oxotetrahydrocarbazoles in reactions with nucleophilic and electrophilic reagents

The half-wave potentials of polarographic reduction of the carbonyl group in unsubstituted and N-methyl- and N-phenylsulfonyl-substituted 1- and 4-oxotetrahydrocarbazoles and their reactivities in reactions with ...

S. Yu. Kukushkin, P. Yu. Ivanov, L. M. Alekseeva, V. I. Levina… in Russian Chemical Bulletin (2005)

Article

Hydrolytic and Reductive Transformations of Nifuroxazide

The elimination of nitro groups in the form of nitrite anions in the course of reduction and alkaline hydrolysis of the antitumor drug nifuroxazide has been studied using polarographic and photometric techniqu...

L. A. Trukhacheva, N. B. Grigor'ev, A. P. Arzamastsev… in Pharmaceutical Chemistry Journal (2005)

Article

Alkaline Hydrolysis Kinetics and No-Donor Activity of Tenonitrozole

The kinetics of alkaline hydrolysis of N-(5-nitro-2-thiazolyl)-2-thiophenylcarboxamide (tenonitrozole or atrican) has been studied by photometric and polarographic techniques, and the thermodynamic parameters in ...

L. A. Trukhacheva, V. I. Levina, A. P. Arzamastsev… in Pharmaceutical Chemistry Journal (2005)

Article

On the reduction of 1-aryl-2-oxo-1,2,3,6-tetra-hydro[1,4]diazepino[6,5-b]indole 4-oxides

Electrochemical reduction of 1-aryl-2-oxo-1,2,3,6-tetrahydro[1,4]diazepino[6,5-b]indole 4-oxides, 2-oxo-1-phenyl-1,2,3,6-tetrahydro[1,4]diazepino[6,5-b]indole, and 2-oxo-1-phenyl-1,2,3,4,5,6-hexahydro[1,4]diazepi...

S. Yu. Ryabova, E. Yu. Khmel’nitskaya, N. A. Rastorgueva… in Russian Chemical Bulletin (2004)

Article

Nitric Oxide Donor Activity of Antihypertensive Drugs Guanoxan, Guanabenz, and Moxonidine

A. V. Danilov, V. A. Azimov, V. I. Levina… in Pharmaceutical Chemistry Journal (2004)

Article

Investigation of the No-Donor Activity of the Antimicrobial Drug Tinidazole

V. I. Levina, L. A. Trukhacheva, N. V. Pyatakova… in Pharmaceutical Chemistry Journal (2004)

Article

Synthesis and Electrochemical Investigation of the NO-Producing Ability of Polynitromethyl 1,3,5-Triazine Derivatives

A. A. Gidaspov, V. V. Bakharev, E. V. Kachanovskaya… in Pharmaceutical Chemistry Journal (2003)

Article

Electrochemical behavior of benzo[b][1,6]naphthyridine derivatives

The electroreduction of benzo[b][1,6]naphthyridine derivatives in anhydrous media by the polarographic method was studied. It is found that the first step of the process is the transfer of an electron to position...

E. Yu. Khmel'nitskaya, A. S. Ivanov, N. Z. Tugusheva… in Russian Chemical Bulletin (2003)

Article

Some Antihypertensive Drugs Clonidine (Clofelin) and Guanfacine - New Nitric Oxide Donors

The presence of in vitro NO-donor characteristics in the antihypertensive drugs clonidine and guanfacine, the structure of which contains a guanidine grou** that relates these drugs to arginine (the main substr...

V. I. Levina, N. V. Pyatakova, O. G. Busygina… in Chemistry of Heterocyclic Compounds (2002)

Article

Study of Oxidation-Reduction Properties and NO-Donor Ability of Dienediamines in the Indole, Pyrrole, and Thiophene Series

We have conducted an electrochemical study of the oxidation-reduction properties of synthesized dienediamines: derivatives of indole, pyrrole, and thiophene. We have established that reduction of the indicated...

E. Yu. Khmel'nitskaya, N. B. Grigor'ev… in Chemistry of Heterocyclic Compounds (2002)

Article

Nitric oxide synthase inhibitors: biology and chemistry

The review is devoted to the problems related to inhibition of the generation of nitric oxide, a versatile regulator of cell metabolism, whose excessive production is responsible for various pathologies. The a...

V. G. Granik, N. B. Grigor"ev in Russian Chemical Bulletin (2002)

Article

Furoxanopyrimidines as Exogenous Donors of Nitric Oxide

V. G. Granik, M. É. Kaminka, N. B. Grigor'ev… in Pharmaceutical Chemistry Journal (2002)

Article

Exogenous donors of nitric oxide (a chemical aspect)

The review considers problems related to the formation, in the living organism, of nitric oxide, a versatile and vitally important regulator of cell metabolism. The pathways of formation of endogenous nitric o...

V. G. Granik, N. B. Grigor"ev in Russian Chemical Bulletin (2002)

Article

7-Aryl-4a-hydroxy-4a,6,7,7a-tetrahydroisoxazolo[4,5-b]quinuclidines as NO Donors

7-Aryl-4a-hydroxy-4a,6,7,7a-tetrahydroisoxazolo[4,5-b]quinuclidines have been prepared from 2-arylmethylene-3-quinuclidones and hydroxylamine and they are able to release NO upon mild oxidation with K₃[Fe(CN₆)] i...

L. N. Koikov, N. V. Alekseeva, N. B. Grigor'ev… in Chemistry of Heterocyclic Compounds (2001)

Article

Nitric-oxide-donor activity of nitrogen-containing compounds estimated by thin-layer chromatography

G. V. Chechekin, B. V. Tyaglov, N. B. Grigor'ev in Pharmaceutical Chemistry Journal (2000)