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1,3,5-Triazinenitrolic acids. Synthesis and NO-releasing properties

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Abstract

Reactions of salts of 1,3,5-triazine dinitromethyl derivatives with nitrogen dioxide that result mainly in 1,3,5-triazinenitrolic acids are investigated. The behavior of nitrolic acid in electroreduction at a mercury drop electrode at various pH was studied; oxygen was shown to accelerate the process. The promoting effect of nitrolic acids on the activity of soluble guanylate cyclase of human platelets was shown. The studied nitrolic acids are active donors of nitric oxide, a universal and important regulator of cell metabolism functions. NO-releasing properties of furoxans are investigated.

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Authors and Affiliations

  1. Samara State University, 244 Molodogvardeiskaya ul., 443100, Samara, Russian Federation

    V. V. Bakharev, A. A. Gidaspov & E. V. Peresedova

  2. Centerfor Drug Chemistry, bld.1, 7 Zubovskaya ul., 119021, Moscow, Russian Federation

    V. G. Granik, N. B. Grigor’ev & V. I. Levina

  3. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, 10 Pogodinskaya ul., 119121, Moscow, Russian Federation

    I. S. Severina & A. Yu. Shchegolev

  4. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    D. E. Dmitriev & A. B. Sheremetev

Authors
  1. V. V. Bakharev
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  2. A. A. Gidaspov
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  3. E. V. Peresedova
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  4. V. G. Granik
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  5. N. B. Grigor’ev
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  6. V. I. Levina
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  7. I. S. Severina
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  8. A. Yu. Shchegolev
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  9. D. E. Dmitriev
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Correspondence to V. G. Granik.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1900–1910, September, 2009.

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Bakharev, V.V., Gidaspov, A.A., Peresedova, E.V. et al. 1,3,5-Triazinenitrolic acids. Synthesis and NO-releasing properties. Russ Chem Bull 58, 1962–1972 (2009). https://doi.org/10.1007/s11172-009-0268-z

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