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Article
Open AccessMisleading localization by 18F-fluorocholine PET/CT in familial hypocalciuric hypercalcemia type-3: a case report
Familial hypocalciuric hypercalcemia (FHH) is a heterogeneous autosomal-dominant disorder of calcium hemostasis that may be difficult to distinguish clinically from mild primary hyperparathyroidism. Loss-of-fu...
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Article
Open AccessFactors underlying surrogate medical decision-making in middle eastern and east Asian women: a Q-methodology study
It is not clear how lay people prioritize the various, sometimes conflicting, interests when they make surrogate medical decisions, especially in non-Western cultures. The extent such decisions are perspective...
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Article
Open AccessVitamin-D2 treatment-associated decrease in 25(OH)D3 level is a reciprocal phenomenon: a randomized controlled trial
Vitamin-D2 (D2) treatment has been associated with a decrease in 25-hydroxy (25(OH)) vitamin-D3 (D3) level, suggesting that D3 treatment would be preferred to raise total 25(OH) vitamin-D (D) level. We postula...
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Article
Open AccessDifferential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial
Vitamin D (D) supplements are indispensable for its world-wide deficiency. Controversy continues on ergocalciferol (D2) and cholecalciferol (D3) relative potency as well as on dosing-schedule and sex role in r...
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Article
Open AccessDrug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design
Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might ...
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Article
Open AccessExploring end of life priorities in Saudi males: usefulness of Q-methodology
Quality end-of-life care depends on understanding patients’ end-of-life choices. Individuals and cultures may hold end-of-life priorities at different hierarchy. Forced ranking rather than independent rating, ...
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Article
Open AccessAcute severe hypothyroidism is not associated with hyponatremia even with increased water intake: a prospective study in thyroid cancer patients
Hypothyroidism, commonly induced in preparation for radioiodine treatment of differentiated thyroid cancer, is a text-book cause for hyponatremia. Nausea, stress, and increased fluid intake associated with the...
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Article
Open AccessInteraction between drug and placebo effects: a cross-over balanced placebo design trial
The total effect of a medication is the sum of its drug effect, placebo effect (meaning response), and their possible interaction. Current interpretation of clinical trials' results assumes no interaction. Dem...
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Article
Radioiodine uptake in inactive pulmonary tuberculosis
Radioiodine may accumulate at sites of inflammation or infection. We have seen such accumulation in six thyroid cancer patients with a history of previously treated pulmonary tuberculosis. We also review the ...
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Article
Patterns of radioiodine uptake by the lactating breast
Breast uptake of radioiodine, if not suspected, may be misinterpreted as thyroid cancer metastasis to the lung. To characterize the patterns of radioiodine breast uptake, we retrospectively studied 20 radioiod...
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Article
False-positive thyroid cancer metastasis on whole-body radioiodine scanning due to retained radioactivity in the oesophagus
In patients with differentiated thyroid cancer, radioiodine uptake in the mediastinal area most often indicates thyroid cancer metastasis. We review 15 radioiodine whole-body scans showing 19 mediastinal artef...