24 Result(s)
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Article
Martin Lacher
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Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-...
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Characterization of the congenital diaphragmatic hernia model in C57BL/6J fetal mice: a step toward lineage tracing experiments
Lineage tracing is key to study the fate of individual cells and their progeny especially in developmental biology. To conduct these studies, we aimed to establish a reproducible model of CDH in the most commo...
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Open AccessCourse of an unplanned and unexpected pregnancy in a 39 year-old patient with Complex bladder extrophy: a case report
With improved operative techniques pregnancy rates have been rising in patients with anomalies of the extrophy-epispadias-complex, including also female patients with bladder extrophy. Specific risks around pr...
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Open AccessReal-time MRI: a new tool of radiologic imaging in small children
Real-time MRI (rt-MRI) in children is a new imaging technique that combines the advantages of US — at frame rates of up to 50 images per second — with the quality and features of MRI. Although still subject of...
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Open AccessDevelopment of an international core outcome set for treatment trials in necrotizing enterocolitis—a study protocol
Necrotizing enterocolitis (NEC) is the most lethal disease of the gastrointestinal tract of preterm infants. New and existing management strategies need clinical evaluation. Large heterogeneity exists in the s...
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Testicular descent revisited: a micro-computed tomography study in fetal rats
There is a long history of research dealing with the embryology of the testicular descent. However, important aspects like the role of the gubernaculum and the development of the processus vaginalis peritonei ...
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Open AccessPectus excavatum in motion: dynamic evaluation using real-time MRI
The breathing phase for the determination of thoracic indices in patients with pectus excavatum is not standardized. The aim of this study was to identify the best period for reliable assessments of morphologi...
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Open AccessA genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy
Classic bladder exstrophy represents the most severe end of all human congenital anomalies of the kidney and urinary tract and is associated with bladder cancer susceptibility. Previous genetic studies identif...
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Langzeitmorbidität und Transition von Kindern mit Ösophagusatresie
Fast täglich wird in Deutschland ein Kind mit Ösophagusatresie (ÖA) geboren. Die Gesamtüberlebensrate hat sich in den letzten Jahrzehnten signifikant verbessert. Auch nach einer erfolgreichen Operation haben P...
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Tenascin C is dysregulated in hypoplastic lungs of miR-200b−/− mice
We previously demonstrated that absence of miR-200b results in abnormal lung development in congenital diaphragmatic hernia due to imbalance between epithelial and mesenchymal cells. Tenascin C is a highly con...
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Musculoskeletal deformities in children with congenital thoracic malformations: a population-based cohort study
It is unclear if musculoskeletal deformities observed in patients with congenital diaphragmatic hernia (CDH), congenital lung lesion (CLL) and esophageal atresia/tracheoesophageal fistula (EA/TEF) are associat...
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Open AccessSurgical treatment of esophageal atresia with lower tracheoesophageal fistula in an extremely preterm infant (510 g, 25 + 5 weeks): a case report
The surgical management of esophageal atresia in extreme-low-birth-weight infants (< 1000 g) is challenging. We report on an extreme-low-birth-weight infant who was extremely preterm (510 g, 25 + 5 weeks) and ...
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Open AccessMidgut development in rat embryos using microcomputed tomography
The development of the mammalian gut was first described more than a century ago. Since then, it has been believed that a series of highly orchestrated developmental processes occur before the intestine achiev...
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Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation
Congenital diaphragmatic hernia (CDH) and congenital pulmonary airway malformation (CPAM) are two inborn pathologies of the lung of unknown origin. Alterations of gene expression in airway epithelial cells are...
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Accidental bladder injury during elective inguinal hernia repair: a preventable complication with high morbidity
Bladder injury (BI) represents a rare complication of inguinal hernia surgery. Protrusions of the urinary bladder through the deep inguinal ring (“bladder ears”) have been reported with an incidence of 9% in i...
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Prenatal maternal biomarkers for the early diagnosis of congenital malformations: A review
Congenital anomalies cause ~7% of all neonatal deaths, many of which have no identified pathophysiological cause. Because accurate and robust laboratory tests are unavailable for most birth defects, physicians...
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The oral microbiome—the relevant reservoir for acute pediatric appendicitis?
The oral microbiome has been related to numerous extra oral diseases. Recent studies detected a high abundance of oral bacteria in inflamed appendices in pediatric patients. To elucidate the role of oral bacteria...
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More than fetal urine: enteral uptake of amniotic fluid as a major predictor for fetal growth during late gestation
The purpose of our study was to investigate the importance of amniotic fluid (AF) for fetal growth during late gestation using esophageal atresia (EA) patients as a model. In this retrospective cohort study, w...
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The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice
Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease in premature infants with high mortality and morbidity with uncertain pathogenesis. Recent research focused on the role of intralu...
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Survey on the management of anorectal malformations (ARM) in European pediatric surgical centers of excellence
Various management strategies for anorectal malformations (ARM) have been proposed. The aim of this study was to assess the current management in centers of excellence in Europe.
