5 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
Mark W. Albers
Article
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Article
Open AccessThe precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is necessary to generate the Aβ peptide, which is implicated in Alzheimer's disease pathology. Studies show that the expression of BACE1 and its p...
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Article
Open AccessA dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line
The immortalized human ReNcell VM cell line represents a reproducible and easy-to-propagate cell culture system for studying the differentiation of neural progenitors. To better characterize the starting line ...
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Article
Open AccessMachine learning identifies candidates for drug repurposing in Alzheimer’s disease
Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Admi...
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Open AccessCausal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may alter dementia onset. Mixed results are emerging from prior observational studies. To address this complexity, we dep...
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Article
Open AccessTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s diseas...
