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  1. No Access

    Article

    Genome doubling shapes the evolution and prognosis of advanced cancers

    Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospec...

    Craig M. Bielski, Ahmet Zehir, Alexander V. Penson, Mark T. A. Donoghue… in Nature Genetics (2018)

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    Article

    Computational Identification and Evolutionary Relationships of the MicroRNA Gene Cluster miR-71/2 in Protostomes

    MicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into ~20–24 nt molecules that can regulate the gene expression post-transcriptionally. MiRNA gene clusters have been identified in a ran...

    Matheus de Souza Gomes, Mark T. A. Donoghue… in Journal of Molecular Evolution (2013)

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    Article

    A phylogenetic approach to test for evidence of parental conflict or gene duplications associated with protein-encoding imprinted orthologous genes in placental mammals

    There are multiple theories on the evolution of genomic imprinting. We investigated whether the molecular evolution of true orthologs of known imprinted genes provides support for theories based on gene duplic...

    Mary J. O’Connell, Noeleen B. Loughran, Thomas A. Walsh… in Mammalian Genome (2010)