-
Article
Open AccessErratum to: Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins
-
Article
Open AccessMolecular adaptation of telomere associated genes in mammals
Placental mammals display a huge range of life history traits, including size, longevity, metabolic rate and germ line generation time. Although a number of general trends have been proposed between these trai...
-
Article
Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome
Walter Kahr and colleagues report mutations in NBEAL2 in gray platelet syndrome (GPS). Using RNA-seq, the authors observed abnormal pre-mRNA processing in NBEAL2 in platelets from an individual with GPS.
-
Article
A phylogenetic approach to test for evidence of parental conflict or gene duplications associated with protein-encoding imprinted orthologous genes in placental mammals
There are multiple theories on the evolution of genomic imprinting. We investigated whether the molecular evolution of true orthologs of known imprinted genes provides support for theories based on gene duplic...
-
Article
Open AccessPositive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins
Reproductive proteins are central to the continuation of all mammalian species. The evolution of these proteins has been greatly influenced by environmental pressures induced by pathogens, rival sperm, sexual ...
-
Article
Open AccessThe phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions
The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase. These enzymes are a...
