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Open AccessExploring the genetics of lithium response in bipolar disorders
Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has bee...
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Article
Open AccessLithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study...
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Open AccessAssociation of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consiste...
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Open AccessCorrection: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
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Article
Open AccessCombining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well unders...
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Article
Metabolomics signatures of acutely ill and short-term weight recovered women with anorexia nervosa
Although metabolomics studies are recently spreading and have allowed the characterization of putative biomarkers in many diseases, they are relatively scanty in anorexia nervosa (AN). In this explorative stud...
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Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bip...
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Article
Open AccessAccuracy of self-assessment of real-life functioning in schizophrenia
A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large (n = 618) cohort of stable, community-dwelling schizophrenia pati...
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Article
Parental bonding, childhood maltreatment and eating disorder psychopathology: an investigation of their interactions
Childhood trauma and parental bonding have been widely recognized as risk factors for eating disorders (EDs). However, their interplay in determining ED psychopathology has been poorly investigated. Consequent...
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Article
Open AccessBeyond diagnosis in psychiatric practice
In psychiatry, the information conveyed by diagnosis (i.e., the “type” to which the individual patient is reconducted) is in itself insufficient for therapeutic and prognostic purposes. Hence the need for a mo...
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Open AccessMental, behavioral and neurodevelopmental disorders in the ICD-11: an international perspective on key changes and controversies
An update of the chapter on Mental, Behavioral and Neurodevelopmental Disorders in the International Classification of Diseases and Related Health Problems (ICD) is of great interest around the world. The rece...
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The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study
The relationships of personal resources with symptom severity and psychosocial functioning have never been tested systematically in a large sample of people with schizophrenia. We applied structural equation m...
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Open AccessClinical Decision Making and Outcome in Routine Care for People with Severe Mental Illness (CEDAR): Study protocol
A considerable amount of research has been conducted on clinical decision making (CDM) in short-term physical conditions. However, there is a lack of knowledge on CDM and its outcome in long-term illnesses, es...
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Financial and non-financial conflicts of interests in psychiatry
A conflict of interests occurs when a doctor is unduly influenced by a secondary interest (i.e., a personal incentive) in his acts concerning one of the primary interests to which he is professionally committe...
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Social skills and neurocognitive individualized training in schizophrenia: comparison with structured leisure activities
Cognitive impairment and deficits in social skills have been largely documented in patients with schizophrenia and are increasingly recognized as rate-limiting factors for recovery. Evidence has been provided ...
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Cerebral connectivity and psychotic personality traits
This study aims to investigate the relationship between regional connectivity in the brain white matter and the presence of psychotic personality traits, in healthy subjects with psychotic traits. Thirteen hea...
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Open AccessRelatives' views on involuntary hospital admission in 8 EUNOMIA sites
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Plasma Leptin and Antipsychotic-Induced Body Weight Gain
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Blood Levels of the Endocannabinoid Anandamide are Increased in Anorexia Nervosa and in Binge-Eating Disorder, but not in Bulimia Nervosa
The endocannabinoid system, consisting of two cannabinoid receptors (CB1 and CB2) and the endogenous ligands anandamide (arachidonoylethanolamide (AEA)) and 2-arachidonoylglycerol (2-AG), has been shown to contro...
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Correlations between negative symptoms and peripheral G protein levels in mononuclear leukocytes of deficit and nondeficit schizophrenics
Receptor-coupled G proteins were measured in mononuclear leukocytes (MNL) of 17 drug-treated patients with deficit schizophrenia (DS) and 16 drug-treated patients with nondeficit schizophrenia (NDS). No signi...