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Article
Open AccessExploring the genetics of lithium response in bipolar disorders
Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has bee...
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Article
Open AccessLithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study...
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Article
Open AccessAssociation of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consiste...
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Article
Open AccessCorrection: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
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Article
Open AccessCombining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well unders...
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Article
Open AccessHLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders
Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and relia...
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Article
Metabolomics signatures of acutely ill and short-term weight recovered women with anorexia nervosa
Although metabolomics studies are recently spreading and have allowed the characterization of putative biomarkers in many diseases, they are relatively scanty in anorexia nervosa (AN). In this explorative stud...
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Article
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bip...
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Article
Open AccessAccuracy of self-assessment of real-life functioning in schizophrenia
A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large (n = 618) cohort of stable, community-dwelling schizophrenia pati...
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Article
Parental bonding, childhood maltreatment and eating disorder psychopathology: an investigation of their interactions
Childhood trauma and parental bonding have been widely recognized as risk factors for eating disorders (EDs). However, their interplay in determining ED psychopathology has been poorly investigated. Consequent...
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Article
Open AccessBeyond diagnosis in psychiatric practice
In psychiatry, the information conveyed by diagnosis (i.e., the “type” to which the individual patient is reconducted) is in itself insufficient for therapeutic and prognostic purposes. Hence the need for a mo...
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Article
Open AccessMental, behavioral and neurodevelopmental disorders in the ICD-11: an international perspective on key changes and controversies
An update of the chapter on Mental, Behavioral and Neurodevelopmental Disorders in the International Classification of Diseases and Related Health Problems (ICD) is of great interest around the world. The rece...
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Article
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9–4% of women and 0.3% of men2–4, with twin-based heritability estimates of 50–60%5. Mortality rat...
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Article
The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study
The relationships of personal resources with symptom severity and psychosocial functioning have never been tested systematically in a large sample of people with schizophrenia. We applied structural equation m...
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Erratum to: Responses of peripheral endocannabinoids and endocannabinoid‑related compounds to hedonic eating in obesity
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The Continuum of Depressive States in the Population and the Differential Diagnosis Between “Normal” Sadness and Clinical Depression
One of the principles of the “neo-kraepelinian credo”, articulated in the 1970s, was that “there is a boundary between the normal and the sick”. In other terms, it was maintained that there is a clear, qualita...
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The Role of Gene Polymorphisms in Susceptibility to Anorexia Nervosa and Bulimia Nervosa
The etiology of anorexia nervosa (AN) and bulimia nervosa (BN) is currently unknown; however, a strong genetic contribution is likely involved. In the last 10 years, several polymorphic variants of genes codin...
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Article
Open AccessClinical Decision Making and Outcome in Routine Care for People with Severe Mental Illness (CEDAR): Study protocol
A considerable amount of research has been conducted on clinical decision making (CDM) in short-term physical conditions. However, there is a lack of knowledge on CDM and its outcome in long-term illnesses, es...
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Article
Financial and non-financial conflicts of interests in psychiatry
A conflict of interests occurs when a doctor is unduly influenced by a secondary interest (i.e., a personal incentive) in his acts concerning one of the primary interests to which he is professionally committe...
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Article
Social skills and neurocognitive individualized training in schizophrenia: comparison with structured leisure activities
Cognitive impairment and deficits in social skills have been largely documented in patients with schizophrenia and are increasingly recognized as rate-limiting factors for recovery. Evidence has been provided ...
