-
Article
Open AccessSignaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological class, is a signaling-specific inhibitor of the cannabinoid r...
-
Article
Open AccessThe CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise...
-
Article
The endocannabinoid system controls food intake via olfactory processes
This study shows that activation of cannabinoid type-1 (CB1) receptors in the olfactory bulb increases odor detection and food intake in hungry mice. The authors show that this function is mediated by CB1-depe...
-
Article
Obesity and the Endocannabinoid System: Circulating Endocannabinoids and Obesity
The endocannabinoid system is critically involved in the regulation of energy balance and represents a potential pharmacotherapeutic target for obesity and type 2 diabetes. New knowledge on the role of this sy...
-
Article
Genetic Dissection of the Role of Cannabinoid Type-1 Receptors in the Emotional Consequences of Repeated Social Stress in Mice
The endocannabinoid system (ECS) tightly controls emotional responses to acute aversive stimuli. Repeated stress alters ECS activity but the role played by the ECS in the emotional consequences of repeated str...
-
Article
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
Lafourcade et al. find that a lifelong insufficiency in dietary n-3 polyunsaturated fatty acids leads to a specific loss of long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal c...
-
Article
Blood Levels of the Endocannabinoid Anandamide are Increased in Anorexia Nervosa and in Binge-Eating Disorder, but not in Bulimia Nervosa
The endocannabinoid system, consisting of two cannabinoid receptors (CB1 and CB2) and the endogenous ligands anandamide (arachidonoylethanolamide (AEA)) and 2-arachidonoylglycerol (2-AG), has been shown to contro...
