8 Result(s)

Article

Intramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome

Wiebke Aderhold, Benjamin Lenz, Marc P. Hübner… in Annals of Hematology (2024)

Article

Hemophagocytic lymphohistiocytosis—how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature

Infection-associated secondary hemophagocytic lymphohistiocytosis (sHLH) is a potentially life-threatening hyperinflammatory condition caused by various infectious diseases. Malaria has rarely been described a...

Hans Martin Orth, Dorothea Wiemer, Sophie Schneitler, Andreas Schönfeld… in Infection (2024)

Article

A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs

The filarial nematode Onchocerca volvulus causes onchocerciasis (river blindness), a neglected tropical disease affecting 21 million people, mostly in Sub-Saharan Africa. Targeting the endosymbiont Wolbachia with...

Stefan Schlabe, Patricia Korir, Christine Lämmer… in Parasitology Research (2022)

Article

Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model

Filariae are vector-borne parasitic nematodes that are endemic worldwide, in tropical and subtropical regions. Important human filariae spp. include Onchocerca volvulus, Wuchereria bancrofti and Brugia spp., and

Frederic Risch, Manuel Ritter, Achim Hoerauf, Marc P. Hübner in Parasitology Research (2021)

Article

Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt ...

Jorge Alvar, Fabiana Alves, Bruno Bucheton, Louise Burrows… in Seminars in Immunopathology (2020)

Article

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

Mice are susceptible to infections with the rodent filarial nematode Litomosoides sigmodontis and develop immune responses that resemble those of human filarial infections. Thus, the L. sigmodontis model is used ...

Stefan J. Frohberger, Jesuthas Ajendra, Jayagopi Surendar… in Parasites & Vectors (2019)

Article

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae con...

Jesuthas Ajendra, Sabine Specht, Sebastian Ziewer, Andrea Schiefer… in Scientific Reports (2016)

Article

Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses

One of the most advantageous research aspects of the murine model of filariasis, Litomosoides sigmodontis, is the availability of mouse strains with varying susceptibility to the nematode infection. In C57BL/6 mi...

Laura E. Layland, Jesuthas Ajendra, Manuel Ritter, Anna Wiszniewsky… in Parasites & Vectors (2015)