7 Result(s)
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Maik Kschischo
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Open AccessGeneration of realistic synthetic data using Multimodal Neural Ordinary Differential Equations
Individual organizations, such as hospitals, pharmaceutical companies, and health insurance providers, are currently limited in their ability to collect data that are fully representative of a disease populati...
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Open AccessLoss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling
Whole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal instability. Yet, erroneously arising human tetraploid cells usually do not p...
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Open AccessSystems approaches identify the consequences of monosomy in somatic human cells
Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find t...
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Open AccessThe p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells
Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitos...
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Open AccessDNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencin...
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Open AccessLearning (from) the errors of a systems biology model
Mathematical modelling is a labour intensive process involving several iterations of testing on real data and manual model modifications. In biology, the domain knowledge guiding model development is in many c...
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Correction: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability
Nature 494, 492–496 (2013); doi:10.1038/nature11935 In this Letter we inadvertently omitted full details of The Cancer Genome Atlas data sets. The Acknowledgements should have included these sentences: “The re...
