7 Result(s)
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Maria Antonietta Cerone
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Article
Open AccessThe Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care
Genomic screening is routinely used to guide the treatment of cancer patients in many countries. However, several multi-layered factors make this effort difficult to deliver within a clinically relevant timefr...
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Open AccessCorrection to: The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care
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Publisher Correction: The National Lung Matrix Trial of personalized therapy in lung cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
The National Lung Matrix Trial of personalized therapy in lung cancer
The majority of targeted therapies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smoke1–3. As this group represen...
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Open AccessDNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencin...
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Open AccessHigh-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
RNA interference (RNAi) screening is a state-of-the-art technology that enables the dissection of biological processes and disease-related phenotypes. The commercial availability of genome-wide, short hairpin ...
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Article
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
We have reconstituted wild type or mutant telomerase activity in two human cell lines that lack constitutive expression of both core subunits of the enzyme and maintain telomeres by a telomerase-independent me...
