7 Result(s)
within
Article
Lucie Chevillard
-
Article
A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations
Dosing regimens of trastuzumab administered by intracerebroventricular (icv) route to patients with HER2-positive brain localizations remain empirical. The objectives of this study were to describe pharmacokin...
-
Article
Open AccessL-carnitine does not improve valproic acid poisoning management: a cohort study with toxicokinetics and concentration/effect relationships
Valproic acid (VPA) poisoning is responsible for life-threatening neurological and metabolic impairments. Despite only low-level evidence of effectiveness, L-carnitine has been used for years to prevent or rev...
-
Article
The neurobehavioral effects of the designer drug naphyrone – an experimental investigation with pharmacokinetics and concentration/effect relationship in mice
The recreational use of naphyrone, a potent synthetic cathinone with a pyrovalerone structure, has raised questions about possible deleterious neurobehavioral consequences.
-
Article
Open AccessNaloxone should remain the appropriate antidote to treat opioid overdose
-
Article
Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships
The use of synthetic cathinones as recreational drugs frequently sold in combination has been increasing exponentially. However, the consequences of combining cathinones on the resulting stimulant effects and ...
-
Article
Open AccessProceedings of Réanimation 2017, the French Intensive Care Society International Congress
-
Article
Open AccessProceedings of Réanimation 2017, the French Intensive Care Society International Congress
