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Open AccessInadequate intensive care physician supply in France: a point-prevalence prospective study
The COVID-19 pandemic has highlighted the importance of intensive care units (ICUs) and their organization in healthcare systems. However, ICU capacity and availability are ongoing concerns beyond the pandemic...
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Article
Parametric Imaging of P-Glycoprotein Function at the Blood–Brain Barrier Using kE,brain-maps Generated from [11C]Metoclopramide PET Data in Rats, Nonhuman Primates and Humans
PET imaging using [11C]metoclopramide revealed the importance of P-glycoprotein (P-gp, ABCB1) in mediating the brain-to-blood efflux of substrates across the blood–brain barrier (BBB). In this work, the eliminati...
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A pharmacological imaging challenge based on 11C-buprenorphine PET-MRI to explore the response to opioids in humans
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Open AccessTemporal trends in calls for suicide attempts to poison control centers in France during the COVID-19 pandemic: a nationwide study
Concerns have been raised about early vs. later impacts of the COVID-19 pandemic on suicidal behavior. However, data remain sparse to date. We investigated all calls for intentional drug or other toxic ingesti...
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Open AccessChronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges
Post‐intensive care syndrome (PICS) encompasses physical, cognition, and mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it significantly impacts the long‐term prognosis, bo...
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Open AccessCorrection to: Energetic dysfunction in sepsis: a narrative review
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Open AccessEnergetic dysfunction in sepsis: a narrative review
Growing evidence associates organ dysfunction(s) with impaired metabolism in sepsis. Recent research has increased our understanding of the role of substrate utilization and mitochondrial dysfunction in the pa...
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Pharmacokinetic neuroimaging to study the dose-related brain kinetics and target engagement of buprenorphine in vivo
A wide range of buprenorphine doses are used for either pain management or maintenance therapy in opioid addiction. The complex in vitro profile of buprenorphine, with affinity for µ-, δ-, and κ-opioid recepto...
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Open AccessManagement of pharmaceutical and recreational drug poisoning
Poisoning is one of the leading causes of admission to the emergency department and intensive care unit. A large number of epidemiological changes have occurred over the last years such as the exponential grow...
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Open AccessNaloxone should remain the appropriate antidote to treat opioid overdose
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Open AccessPreclinical septic shock research: why we need an animal ICU
Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation ...
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Unusual purpura fulminans after heart transplantation
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Open AccessLoxapine to control agitation during weaning from mechanical ventilation
Weaning from mechanical ventilation (MV) may be impeded by the occurrence of agitation. Loxapine has the ability to control agitation without affecting spontaneous ventilation. The aim of this study was to est...
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Open AccessProceedings of Réanimation 2017, the French Intensive Care Society International Congress
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When intra-aortic balloon pump is intra-abdominal balloon pump
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Intoxications aiguës
14 % de l’activité des réanimations en France, mortalité 6,8 %.
Adultes : majoritairement volon...
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Article
Drug Fever
Background: Although known as a rare adverse drug reaction (ADR), drug fever (DF) remains an important issue in medicine, with the risk of leading to inappropriate and potentially harmful diagnostic and therapeu...
