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Open AccessThe association between satisfaction with life and anxiety symptoms among Chinese elderly: a moderated mediation analysis
Previous studies have suggested that certain personal psychological variables (e.g., life satisfaction and cognitive function) and physical variables (e.g., body mass index [BMI]) are significantly associated ...
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Article
The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study
The role of CD3+CD56+ natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown. In this prospective observational cohort study, we initially r...
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Continuous electronic state regulation by tunable Mott–Schottky Heterojunction potential boosting C-C cleavage for ethanol oxidation
The efficiency of direct ethanol fuel cells has been limited by the low performance of ethanol oxidation reaction (EOR) due to the high energy barrier for C–C bond cleavage via the C1 pathway, and thus the design...
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Article
Open AccessCausal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis
Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear. This study aims to investig...
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Article
Open AccessAnomalous isotope effect on mechanical properties of single atomic layer Boron Nitride
The ideal mechanical properties and behaviors of materials without the influence of defects are of great fundamental and engineering significance but considered inaccessible. Here, we use single-atom-thin isot...
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Article
Open AccessNeutrophil levels upon admission for the assessment of acute pulmonary embolism with intermediate- and high-risk: an indicator of thrombosis and inflammation
Risk prediction rules are important to establish appropriate treatment and management strategy for patients with different risk classification of pulmonary embolism (PE). Neutrophils are considered to be relat...
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Article
Toward a function realization of multi-scale modeling for lithium-ion battery based on CHAIN framework
As the most mature portable power source, lithium-ion battery has become the mainstream of power source for electric vehicles (EVs) by virtue of its high energy density, long cycle life and relatively low cost...
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Article
β2-adrenergic receptor drives the metastasis and invasion of pancreatic ductal adenocarcinoma through activating Cdc42 signaling pathway
Recent investigations indicate that β2-adrenergic receptor (β2-AR) signaling may facilitate the progression of various tumors, whose underlying mechanisms remain largely elusive. In the present study, we showe...
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Plasma metabolomics in the perioperative period of defect repair in patients with pulmonary arterial hypertension associated with congenital heart disease
The quality of life and survival rates of patients with pulmonary arterial hypertension associated with congenital heart disease (CHD–PAH) have been greatly improved by defect-repair surgery and personalized t...
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Article
The long-term survival in patients with chronic thromboembolic pulmonary hypertension: experience from a single center in China
The long-term prognosis of patients with chronic thromboembolic pulmonary hypertension (CTEPH) receiving different treatments is deserved to be analyzed in modern era of CTEPH treatment. From 2013 to 2019, a t...
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Article
Open AccessSafety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...
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Thrombus straddling a patent foramen ovale in a patient with pulmonary embolism related to essential thrombocythemia
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Open AccessNumerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation
The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in previous researches. In fact, microcir...
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Article
Discovery of oscillations above 200 keV in a black hole X-ray binary with Insight-HXMT
Low-frequency quasiperiodic oscillations (LFQPOs) are commonly found in black hole X-ray binaries, and their origin is still under debate. The properties of LFQPOs at high energies (above 30 keV) are closely r...
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Article
Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism
Normotensive patients with acute pulmonary embolism (APE) are accompanied by heterogeneously adverse events. Responding to tissue injury, lipocalin-2 (LCN-2) is elevated in experimental APE model and associate...
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Article
Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach
Chinese herbal medicine (CHM) addresses complex diseases through polypharmacological interactions. However, systematic studies of herbal medicine pharmacology remain challenging due to the complexity of CHM in...
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Article
A Novel Polarization Filter Based on Photonic Crystal Fiber with a Single Au-Coated Air Hole and Semi-Hourglass Structure
A polarization filter that has a novel photonic crystal fiber structure of semi-hourglass part and Au-coated film is proposed. We simulated the performance of the structure by the finite element method. The nu...
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Article
A hemodynamic model with a seepage condition and fluid–structure interactions for blood flow in arteries with symmetric stenosis
To strengthen the detailed understanding of arterial stenosis, we construct a novel hemodynamic model. Frequently used symmetric stenosis is employed in this work. Being different from a traditional model, thi...
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Article
Ultra-short and broadband polarization splitter based on PCF and metal surface plasmons resonance
An ultra-short and broadband polarization splitter based on PCF and metal surface plasmons resonance is proposed by designing a new structure and filling gold wire into certain air holes. The introducing of go...
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Two-dimensional Na–Cl crystals of unconventional stoichiometries on graphene surface from dilute solution at ambient conditions
NaCl in a 1:1 stoichiometry is the only known stable form of the Na–Cl crystal under ambient conditions, and non-1:1 Na–Cl species can only form under extreme conditions, such as high pressures. Here we report...