32 Result(s)
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Article
Lu Han
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessRewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula
Class I KNOTTED-like homeobox (KNOXI) genes are parts of the regulatory network that control the evolutionary diversification of leaf morphology. Their specific spatiotemporal expression patterns in develo** le...
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Open AccessTargeting P2Y14R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis
Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease. Among purinoceptors, only P2Y14R is positively correlated with inflammatory score in mucosal biopsies of ulcerative coli...
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Open AccessA dual-crosslinking electroactive hydrogel based on gelatin methacrylate and dibenzaldehyde-terminated telechelic polyethylene glycol for 3D bio-printing
Gelatin was widely used as scaffold materials in 3D bio-printing due to its excellent bioactivity and availability and especially that their arginine–glycine–aspartic acid (RGD) sequences could efficiently pro...
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Open AccessAtherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macroph...
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Open AccessDevelo** mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library
DddA-derived cytosine base editors (DdCBEs) greatly facilitated the basic and therapeutic research of mitochondrial DNA mutation diseases. Here we devise a saturated spacer library and successfully identify se...
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Open AccessDevelopment of a BIM-based bridge maintenance system (BMS) for managing defect data
Bridges might experience many defects during use, such as pavement cracks and reinforcement corrosion, which easily produce an accumulated impact that threatens bridge safety. Thus, there is a need for the reg...
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Open AccessThe splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis
Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the major cellular component. Howe...
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Open AccessSynchronous quantitative analysis of chiral mesostructured inorganic crystals by 3D electron diffraction tomography
Chiral mesostructures exhibit distinctive twisting and helical hierarchical stacking ranging from atomic to micrometre scales with fascinating structural-chiral anisotropy properties. However, the detailed det...
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Open AccessGenetic abnormalities in fetal congenital heart disease with aberrant right subclavian artery
Fetal aberrant right subclavian artery (ARSA) is a relatively common sonographic finding. Congenital heart disease (CHD) is the most common structural abnormality in patients with ARSA. We aimed to assess the ...
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Open AccessEnhanced polarization and abnormal flexural deformation in bent freestanding perovskite oxides
Recent realizations of ultrathin freestanding perovskite oxides offer a unique platform to probe novel properties in two-dimensional oxides. Here, we observe a giant flexoelectric response in freestanding BiFeO3 ...
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High-density switchable skyrmion-like polar nanodomains integrated on silicon
Topological domains in ferroelectrics1–5 have received much attention recently owing to their novel functionalities and potential applications6,7 in electronic devices. So far, however, such topological polar str...
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Open AccessAdditive manufacturing of strong silica sand structures enabled by polyethyleneimine binder
Binder Jet Additive Manufacturing (BJAM) is a versatile AM technique that can form parts from a variety of powdered materials including metals, ceramics, and polymers. BJAM utilizes inkjet printing to selectiv...
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Open AccessA candidate gene identified in converting platycoside E to platycodin D from Platycodon grandiflorus by transcriptome and main metabolites analysis
Platycodin D and platycoside E are two triterpenoid saponins in Platycodon grandiflorus, differing only by two glycosyl groups structurally. Studies have shown β-Glucosidase from bacteria can convert platycoside ...
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Open AccessTriptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates
There are no non-hormonal male contraceptives currently on the market despite decades of efforts toward the development of “male pills”. Here, we report that triptonide, a natural compound purified from the Ch...
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Open AccessSingle cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
Visceral organs, such as the lungs, stomach and liver, are derived from the fetal foregut through a series of inductive interactions between the definitive endoderm (DE) and the surrounding splanchnic mesoderm...
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Open AccessConjuncted photo-thermoelectric effect in ZnO–graphene nanocomposite foam for self-powered simultaneous temperature and light sensing
The self-powered sensors are more and more important in current society. However, detecting both light and temperature signals simultaneously without energy waste and signal interference is still a challenge. ...
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Open AccessRoom-temperature direct synthesis of semi-conductive PbS nanocrystal inks for optoelectronic applications
Lead sulphide (PbS) nanocrystals (NCs) are promising materials for low-cost, high-performance optoelectronic devices. So far, PbS NCs have to be first synthesized with long-alkyl chain organic surface ligands ...
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Freestanding crystalline oxide perovskites down to the monolayer limit
Two-dimensional (2D) materials such as graphene and transition-metal dichalcogenides reveal the electronic phases that emerge when a bulk crystal is reduced to a monolayer1–4. Transition-metal oxide perovskites h...
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Open AccessWarming in the Agulhas Region during the Global Surface Warming Acceleration and Slowdown
The Agulhas Region gains more heat during the global surface warming slowdown than acceleration period. Yet, mechanisms that cause excessive heat accumulation in this region remain largely unknown. We investig...
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Open AccessTuning charge carrier transport and optical birefringence in liquid-crystalline thin films: A new design space for organic light-emitting diodes
Liquid-crystalline organic semiconductors exhibit unique properties that make them highly interesting for organic optoelectronic applications. Their optical and electrical anisotropies and the possibility to c...
