43 Result(s)

Article

BASALT refines binning from metagenomic data and increases resolution of genome-resolved metagenomic analysis

Metagenomic binning is an essential technique for genome-resolved characterization of uncultured microorganisms in various ecosystems but hampered by the low efficiency of binning tools in adequately recoverin...

Zhiguang Qiu, Li Yuan, Chun-Ang Lian, Bin Lin, Jie Chen, Rong Mu… in Nature Communications (2024)

Article

Editorial Expression of Concern: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system

**aowei Lu, Ferdinand le Noble, Li Yuan, Quingjan Jiang, Benjamin de Lafarge… in Nature (2024)

Article

Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial

Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for refractory recurrent/metastatic nasopharyngeal carcinom...

Li Yuan, Guo-Dong Jia, **ao-Fei Lv, Si-Yi **e, Shan-Shan Guo… in Nature Communications (2023)

Article

Integrative proteomic characterization of adenocarcinoma of esophagogastric junction

The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics an...

Shengli Li, Li Yuan, Zhi-Yuan Xu, **g-Li Xu, Gui-** Chen… in Nature Communications (2023)

Article

Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients

This study aimed to investigate the correlation between the severity of photoreceptor damage and the level of anti-retina antibodies (ARAs) in aqueous humor, including recoverin, CA II and enolase-α IgG antibo...

**nyao Han, Linqi Zhang, Jiyang Tang, Zongyi Wang, Siying Li, Li Yuan… in Scientific Reports (2022)

Article

Endoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study

A new approach by investigating the intra-tumoral microbiome raised great interest because they may influence the host immune response and natural history of the disease. However, previous studies on the intra...

Chia-Sheng Chu, Chi-Ying Yang, Chun-Chieh Yeh, Ro-Ting Lin… in Scientific Reports (2022)

Article

Survival outcomes of management in metastatic gastric adenocarcinoma patients

Chemotherapy is generally considered as the main treatment for metastatic gastric adenocarcinoma. The role of gastrectomy for metastatic gastric cancer without obvious symptoms is controversial. The objective ...

Huang-Ming Hu, Hui-Jen Tsai, Hsiu-Ying Ku, Su-Shun Lo, Yan-Shen Shan… in Scientific Reports (2021)

Article

The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus

The sperm head-to-tail coupling apparatus (HTCA) ensures sperm head-tail integrity while defective HTCA causes acephalic spermatozoa, rendering males infertile. Here, we show that CENTLEIN is indispensable for...

Ying Zhang, Chao Liu, Bingbing Wu, Liansheng Li, Wei Li, Li Yuan in Nature Communications (2021)

Article

The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characteris...

Liu Teng, Yu Chen Feng, Su Tang Guo, Pei Lin Wang, Teng Fei Qi… in Nature Communications (2021)

Article

Author Correction: A new coronavirus associated with human respiratory disease in China

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Fan Wu, Su Zhao, Bin Yu, Yan-Mei Chen, Wen Wang, Zhi-Gang Song, Yi Hu… in Nature (2020)

Article

Super impact stable TATB explosives recrystallized by bicarbonate ionic liquids with a record solubility

Ensuring the security for long-term storage of weapons is always of the great cMehilaloncerns in the field of energetic materials. 1,3,5-Triamino-2,4,6-trinitrobenzene (TATB) is a remarkable explosive applied ...

Wen-Li Yuan, Guo-Hong Tao, Lei Zhang, Zhang Zhang, Ying Xue, Ling He… in Scientific Reports (2020)

Article

A new coronavirus associated with human respiratory disease in China

Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health^1–3. Despite intense research efforts, how, when and where new disease...

Fan Wu, Su Zhao, Bin Yu, Yan-Mei Chen, Wen Wang, Zhi-Gang Song, Yi Hu… in Nature (2020)

Article

Author Correction: FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Li-Yuan Bai, Chang-Fang Chiu, Shih-Jiuan Chiu, Po-Chen Chu… in Scientific Reports (2020)

Article

Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRC...

**ang-Ming Wang, Yang Lu, Yi-Meng Song, Jun Dong, Ruo-Yan Li… in Nature Communications (2020)

Article

Bone secreted factors induce cellular quiescence in prostate cancer cells

Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site(s) before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can occur years after prostatectom...

Li-Yuan Yu-Lee, Yu-Chen Lee, **g Pan, Song-Chang Lin, Tianhong Pan… in Scientific Reports (2019)

Article

Numerical Simulation of Mandible Bone Remodeling under Tooth Loading: A Parametric Study

Bone adapts to the change of mechanical stimulus by bone remodeling activities. A number of numerical algorithms have been developed to model the adaptive bone remodeling under mechanical loads for orthopedic ...

Kangning Su, Li Yuan, Jie Yang, **g Du in Scientific Reports (2019)

Article

Role of fundoplication in treatment of patients with symptoms of hiatal hernia

Gastroesophageal reflux disease (GERD) is often associated with hiatal hernia (HH). However, the need for fundoplication during hiatal hernia repair (HHR) remains controversial. The objective of this study was...

Zhi-tong Li, Feng Ji, **n-wei Han, Li-li Yuan, Zheng-yang Wu, Miao Xu… in Scientific Reports (2019)

Article

GmSYP24, a putative syntaxin gene, confers osmotic/drought, salt stress tolerances and ABA signal pathway

As major environment factors, drought or high salinity affect crop growth, development and yield. Transgenic approach is an effective way to improve abiotic stress tolerance of crops. In this study, we compara...

Li-Miao Chen, Yi-Sheng Fang, Chan-Juan Zhang, Qing-Nan Hao, Dong Cao… in Scientific Reports (2019)

Article

Management of glycemic variation in diabetic patients receiving parenteral nutrition by continuous subcutaneous insulin infusion (CSII) therapy

To compare the continuous subcutaneous insulin infusion (CSII) or insulin glargine based multiple injections (MDI) therapy on glycemic variations in diabetic patients receiving PN outside of intensive care set...

Feng-fei Li, Wen-li Zhang, Bing-li Liu, Dan-feng Zhang, Wei Chen… in Scientific Reports (2018)

Article

TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury

Transient receptor potential melastatin 7 (TRPM7) is a membrane ion channel and kinase. TRPM7 was abundantly expressed in the kidney, and up-regulated by ischemia reperfusion (IR) injury. Our previous studies ...

Aifen Liu, **g Wu, Cheng Yang, Yuanyuan Wu, Yufang Zhang… in Scientific Reports (2018)