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Integrative microbiomics in bronchiectasis exacerbations
Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. We present an approach to the multi-biome that integrates bacterial, viral and fungal communities...
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Open Access26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3
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Open Access25th Annual Computational Neuroscience Meeting: CNS-2016
A1 Functional advantages of cell-type heterogeneity in neural circuits
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Open AccessBifurcation analysis of a two-compartment hippocampal pyramidal cell model
The Pinsky-Rinzel model is a non-smooth 2-compartmental CA3 pyramidal cell model that has been used widely within the field of neuroscience. Here we propose a modified (smooth) system that captures the qualita...
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Open AccessBeyond in-phase and anti-phase coordination in a model of joint action
In 1985, Haken, Kelso and Bunz proposed a system of coupled nonlinear oscillators as a model of rhythmic movement patterns in human bimanual coordination. Since then, the Haken–Kelso–Bunz (HKB) model has becom...
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Open AccessInvestigating the effects of beta-amyloid on hippocampal signalling in Alzheimer's disease
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Open AccessModulation of hippocampal gamma oscillations by acetylcholine: insights from mathematical and in vitro optogenetic models
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Open AccessTRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model
Sarcoplasmic/endoplasmic reticulum (SR) and nuclear membranes contain two related cation channels named TRIC-A and TRIC-B. In many tissues, both subtypes are co-expressed, making it impossible to distinguish t...
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Open AccessSensitivity analysis to explain the excitability in a pyramidal neuron with application to Alzheimer’s disease