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Article
Open AccessSmoking during pregnancy and its effect on placental weight: a Mendelian randomization study
The causal relationship between maternal smoking in pregnancy and reduced offspring birth weight is well established and is likely due to impaired placental function. However, observational studies have given ...
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Article
Open AccessThe prospect of artificial intelligence to personalize assisted reproductive technology
Infertility affects 1-in-6 couples, with repeated intensive cycles of assisted reproductive technology (ART) required by many to achieve a desired live birth. In ART, typically, clinicians and laboratory staff...
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Chapter and Conference Paper
Effects of Controller-Induced Dynamics on Experimental Bifurcation Analysis
Control-based continuation (CBC) is an experimental method that uses feedback control to probe the dynamics of a physical system. CBC relies on finding control targets that render the control system noninvasiv...
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Article
Open AccessUsing immersive virtual reality to remotely examine performance differences between dominant and non-dominant hands
Circle drawing may be a useful task to study upper-limb function in patient populations. However, previous studies rely on expensive and bulky robotics to measure performance. For clinics or hospitals with lim...
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Article
Open AccessNumerical methods for control-based continuation of relaxation oscillations
Control-based continuation (CBC) is an experimental method that can reveal stable and unstable dynamics of physical systems. It extends the path-following principles of numerical continuation to experiments an...
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Article
Open AccessSynthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage
Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are desperately needed, as are research tools to aid in their discovery and development. Vancomycin is a glycopeptide a...
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Article
Open AccessAlgorithmic hospital catchment area estimation using label propagation
Hospital catchment areas define the primary population of a hospital and are central to assessing the potential demand on that hospital, for example, due to infectious disease outbreaks.
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Article
Open AccessNutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells
The interaction between a cell and its environment shapes fundamental intracellular processes such as cellular metabolism. In most cases growth rate is treated as a proximal metric for understanding the cellul...
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Reference Work Entry In depth
Spike-Timing Dependent Plasticity (STDP), Biophysical Models
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Article
Open AccessEstimating disease prevalence in large datasets using genetic risk scores
Clinical classification is essential for estimating disease prevalence but is difficult, often requiring complex investigations. The widespread availability of population level genetic data makes novel genetic...
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Article
Open AccessReduced Models of Cardiomyocytes Excitability: Comparing Karma and FitzHugh–Nagumo
Since Noble adapted in 1962 the model of Hodgkin and Huxley to fit Purkinje fibres, the refinement of models for cardiomyocytes has continued. Most of these models are high-dimensional systems of coupled equat...
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Article
Integrative microbiomics in bronchiectasis exacerbations
Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. We present an approach to the multi-biome that integrates bacterial, viral and fungal communities...
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Article
Correction to: Decoding identity from motion: how motor similarities colour our perception of self and others
The article Decoding identity from motion: how motor similarities colour our perception of self and others, written by Alexandre Coste, Benoît G, Bardy, Stefan Janaqi, Piotr Słowiński, Krasimira Tsaneva-Atanas...
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Article
Open AccessDecoding identity from motion: how motor similarities colour our perception of self and others
For more than 4 decades, it has been shown that humans are particularly sensitive to biological motion and extract socially relevant information from it such as gender, intentions, emotions or a person’s ident...
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Article
Open AccessscReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets
Recently, pioneering expression quantitative trait loci (eQTL) studies on single cell RNA sequencing (scRNA-seq) data have revealed new and cell-specific regulatory single nucleotide variants (SNVs). Here, we ...
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Chapter and Conference Paper
SOMiMS - Topographic Map** in the Model Space
Learning in the model space (LiMS) represents each observational unit (e.g. sparse and irregular time series) with a suitable model of it (point estimate), or a full posterior distribution over models. LiMS ap...
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Article
Open AccessMeasuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader
Normal reproductive functioning is critically dependent on pulsatile secretion of luteinising hormone (LH). Assessment of LH pulsatility is important for the clinical diagnosis of reproductive disorders, but c...
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Article
Open AccessGaze training supports self-organization of movement coordination in children with developmental coordination disorder
Children with developmental coordination disorder (DCD) struggle with the acquisition of coordinated motor skills. This paper adopts a dynamical systems perspective to assess how individual coordination soluti...
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Article
Open AccessSequential escapes: onset of slow domino regime via a saddle connection
We explore sequential escape behaviour of coupled bistable systems under the influence of stochastic perturbations. We consider transient escapes from a marginally stable “quiescent” equilibrium to a more sta...
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Article
Open AccessRelaxation oscillations and canards in the Jirsa–Kelso excitator model: global flow perspective
Fenichel’s geometric singular perturbation theory and the blow-up method have been very successful in describing and explaining global non-linear phenomena in systems with multiple time-scales, such as relaxa...