5 Result(s)

Article

Tau^P301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurode...

Katriona L. Hole, Bangfu Zhu, Laura Huggon, Jon T. Brown… in Cell Death & Disease (2024)

Article

Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons

Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R or 4R) and exhibit no (0N), one (1N) or two (2N) N ...

Georgiana F. Stan, Timothy W. Church, Ellie Randall… in Scientific Reports (2022)

Article

EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease

The dynamics of the resting brain exhibit transitions between a small number of discrete networks, each remaining stable for tens to hundreds of milliseconds. These functional microstates are thought to be the...

Luke Tait, Francesco Tamagnini, George Stothart, Edoardo Barvas… in Scientific Reports (2020)

Article

Sensitivity analysis to explain the excitability in a pyramidal neuron with application to Alzheimer’s disease

Jakub Nowacki, Hinke M Osinga, Jon T Brown, Andrew D Randall… in BMC Neuroscience (2011)

Article

Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein

Aβ peptides derived from the cleavage of amyloid precursor protein are widely believed to play an important role in the pathophysiology of Alzheimer's disease. A common way to study the impact of these molecul...

Jonathan Witton, Jon T Brown, Matthew W Jones, Andrew D Randall in Molecular Brain (2010)