31,383 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Ke** Zhang
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Open AccessFar-infrared therapy promotes exercise capacity and glucose metabolism in mice by modulating microbiota homeostasis and activating AMPK
The benefits of physical exercise on human health make it desirable to identify new approaches that would mimic or potentiate the effects of exercise to treat metabolic diseases. However, whether far-infrared ...
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Open AccessPolystyrene nanoplastics of different particle sizes regulate the polarization of pro-inflammatory macrophages
Microplastics (MPs) are defined as plastic particles smaller than 5 mm in size, and nanoplastics (NPs) are those MPs with a particle size of less than 1000 nm or 100 nm. The prevalence of MPs in the environmen...
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Open AccessAdenine base editing-mediated exon skip** restores dystrophin in humanized Duchenne mouse model
Duchenne muscular dystrophy (DMD) affecting 1 in 3500–5000 live male newborns is the frequently fatal genetic disease resulted from various mutations in DMD gene encoding dystrophin protein. About 70% of DMD-caus...
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Open AccessThe SIRT2-AMPK axis regulates autophagy induced by acute liver failure
This study explores the role of SIRT2 in regulating autophagy and its interaction with AMPK in the context of acute liver failure (ALF). This study investigated the effects of SIRT2 and AMPK on autophagy in AL...
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Open AccessSingle-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive. Here...
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Open AccessPre-IVM with C-type natriuretic peptide promotes mitochondrial biogenesis of bovine oocytes via activation of CREB
The aim of this study was to evaluate the effects of C-type natriuretic peptide (CNP) treatment prior to in vitro maturation (IVM) on mitochondria biogenesis in bovine oocyte matured in vitro and explore the r...
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Open AccessPrevalence and trends in overactive bladder among men in the United States, 2005–2020
The purpose of present study was to examine the current prevalence and recent trends of overactive bladder (OAB) among US adult men and examine the correlations between OAB and several potential risk factors. ...
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Open AccessLarge-scale 2D heterostructures from hydrogen-bonded organic frameworks and graphene with distinct Dirac and flat bands
The current strategies for building 2D organic-inorganic heterojunctions involve mostly wet-chemistry processes or exfoliation and transfer, leading to interface contaminations, poor crystallizing, or limited ...
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Open AccessAI-NERD: Elucidation of relaxation dynamics beyond equilibrium through AI-informed X-ray photon correlation spectroscopy
Understanding and interpreting dynamics of functional materials in situ is a grand challenge in physics and materials science due to the difficulty of experimentally probing materials at varied length and time...
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Open AccessSustained North Atlantic warming drove anomalously intense MIS 11c interglacial
The Marine Isotope Stage (MIS) 11c interglacial and its preceding glacial termination represent an enigmatically intense climate response to relatively weak insolation forcing. So far, a lack of radiometric ag...
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Open AccessNative mass spectrometry and structural studies reveal modulation of MsbA–nucleotide interactions by lipids
The ATP-binding cassette (ABC) transporter, MsbA, plays a pivotal role in lipopolysaccharide (LPS) biogenesis by facilitating the transport of the LPS precursor lipooligosaccharide (LOS) from the cytoplasmic t...
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Open AccessEfficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality, inter-batch consistency, cryopreservation and scale remain, reducing...
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Open AccessIntratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers
Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in AC...
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Open AccessLegionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms
The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions by secreting multiple effectors with diverse biochemical activities. In particular, effectors of the SidE family interfere...
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Open AccessA combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models
Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable d...
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Open Access\(\text{Sech}^{2}\) -type solitary waves and the stability analysis for the KdV–mKdV equation
In this article, we investigated the solitary wave solutions of the KdV–mKdV equation using Hirota’s bilinear method. Closed-form analytical single and multiple solitary wave solutions were obtained. Through q...
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Open AccessAnalytical realization of complex thermal meta-devices
Fourier’s law dictates that heat flows from warm to cold. Nevertheless, devices can be tailored to cloak obstacles or even reverse the heat flow. Mathematical transformation yields closed-form equations for gr...
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Open AccessPrenatal genetic diagnosis of fetuses with dextrocardia using whole exome sequencing in a tertiary center
To evaluate the genetic etiology of fetal dextrocardia, associated ultrasound anomalies, and perinatal outcomes, we investigated the utility of whole exome sequencing (WES) for prenatal diagnosis of dextrocard...
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Open AccessImpact of corrupt admission on the mental health of Chinese adolescents
Through preferential treatment by education officials or through bribery, some adolescents can obtain admission to a junior high school. However, it is unclear whether it affects the mental health of adolescen...
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Open AccessFibroblast growth factor 23 inhibition attenuates steroid-induced osteonecrosis of the femoral head through pyroptosis
Steroid-induced osteonecrosis of the femoral head (SONFH) is the predominant cause of non-traumatic osteonecrosis of the femoral head (ONFH). Impaired blood supply and reduced osteogenic activity of the femora...
