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Article
Open AccessProperty parameter determination in individual layers for separately fractured wells with commingled production in multi-layered reservoirs
At present, without any separate rate test for each layer, there is no way to determinate the properties of individual layers for separately fractured wells with commingled production in multi-layered reservoi...
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Article
Open AccessMultidrug-resistant bacterial infection in adult patients following cardiac surgery: clinical characteristics and risk factors
The prevalence of infections with multidrug-resistant organism (MDRO) pose great challenges for anti-infective therapy. Previous research on MDRO infections after cardiac surgery was limited. Therefore, unders...
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Chapter and Conference Paper
MSPP-IQA: Adaptive Blind Image Quality Assessment Based on Multi-level Spatial Pyramid Pooling
The main reason why image quality assessment (IQA) for real distortion has not been well solved is that, first, after the training of CNN is completed, the parameters of the convolution kernel are fixed, but t...
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Article
Open AccessRegional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways
DNA 5-hydroxymethylcytosine (5hmC) is produced by dynamic 5mC oxidation process contributing to tissue specification, and loss of 5hmC has been reported in multiple cancers including genitourinary cancers. How...
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Article
Open AccessDNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma
At present, the extent and clinical relevance of epigenetic differences between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) remain largely unknown. Here, we conducted ...
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Article
Open AccessFrameshift and wild-type proteins are often highly similar because the genetic code and genomes were optimized for frameshift tolerance
Frameshift mutations have been considered of significant importance for the molecular evolution of proteins and their coding genes, while frameshift protein sequences encoded in the alternative reading frames ...
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Article
Open AccessBiological roles of RNA m5C modification and its implications in Cancer immunotherapy
Epigenetics including DNA and RNA modifications have always been the hotspot field of life sciences in the post-genome era. Since the first map** of N6-methyladenosine (m6A) and the discovery of its widespread ...
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Article
Osthole: an overview of its sources, biological activities, and modification development
Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and separation from plants or total syn...
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Article
Sports combination training action recognition based on SMO algorithm optimization model
In sports combined training, the artificial intelligence recognition system can effectively improve the training effect, but the impact of complex background will lead to lower recognition accuracy. In order t...
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Article
Open AccessThe key roles of cancer stem cell-derived extracellular vesicles
Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading to tumor progression and metas...
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Article
Open AccessIntercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer
Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell lung cancer (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients w...
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Article
Open AccessExosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1
Exosomes play critical roles in regulating various physiological and pathological processes, including immune stimulation, immune suppression, cardiovascular diseases, and cancers. Recent studies show that exo...
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Chapter and Conference Paper
Dimension Reduction Algorithm of Big Data Based on Deep Neural Network
Dimensionality reduction refers to map** data from high-dimensional space to a low-dimensional space, which is the main method of high-dimensional data mining. The restricted Boltzmann machine, the basic str...
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Article
Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney
Chronic kidney disease is a severe threat to human health with no ideal treatment strategy. Mature mammalian kidneys have a fixed number of nephrons, and regeneration is difficult once they are damaged. For th...
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Article
Open AccessMED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC
Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, th...
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Chapter and Conference Paper
Build-up Analysis of Multi-Well System in Naturally Fractured HTHP Gas Reservoirs
In order to clarify reservoir characteristics and identify pressure build-up characteristics resulting from the offset effect, well test models of bottomhole pressure in the multi-well system of infinite homog...
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Article
Difference in regional neural fluctuations and functional connectivity in Crohn’s disease: a resting-state functional MRI study
Patients with Crohn’s disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity...
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Article
The Impact of Irrigation on Bacterial Community Composition and Diversity in Liaohe Estuary Wetland
In this study, the sequencing of 16S ribosomal DNA was used to characterize the soil bacterial community composition and diversity in Liaohe estuarine wetland. Soil samples were taken from different locations ...
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Article
Open AccessA novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progress...
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Article
Open AccessDacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo
ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and d...
