2,782 Result(s)
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Biomedicine
Neurobiology
Neurosciences
Ke** Zhang
Article
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Article
How to unconfound the directional and orientational information in visual neuron's response
When drifting bars or gratings are used as visual stimuli, information about orientation specificity (which has a period of 180°) and direction specificity (which has a period of 360°) is inherently confounded...
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A mathematical model for resolution enhancement in layered sensory systems
Heiligenberg (1987) recently proposed a model to explain how the representation of a stimulus variable through an ordered array of broadly tuned receptors could allow a degree of stimulus resolution greatly ex...
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Immunocytochemical staining with antibodies against protein kinase C and its isozymes in the turtle retina
An LM immunocytochemical study has investigated the patterns of staining in turtle retina with monoclonal antibodies to the α, β and γ isozymes of protein kinase C. The protein kinase C-γ antibody reveals cell...
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Effect of peripheral nerve cut on neuropeptides in dorsal root ganglia and the spinal cord of monkey with special reference to galanin
Using the indirect immunofluorescence method andin situ hybridization, the localization and levels of immunoreactivities and mRNAs for several neuropeptides were studied in lumbar dorsal root ganglia and spinal c...
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Tenascin-C expression by neurons and glial cells in the rat spinal cord: Changes during postnatal development and after dorsal root or sciatic nerve injury
We have usedin situ hybridization with a digoxigenin-labelled probe for tenascin-C mRNA and immunocytochemistry with antibodies against tenascin-C, glial fibrillary acidic protein, OX-42 and the 200 kDa neurofila...
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Correlation of receptive field position of mechanosensory neurons and the strength of their connections to AP neurons in the CNS of the leech (Whitmania pigra)
An identified neuron of unknown function in the CNS of the leech, the anterior pagoda (AP) cell, receives multiple synaptic inputs from mechanosensory neurons that innervate the skin. Impulses in touch (T), pr...
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Expression of platelet-derived growth factor (PDGF) receptor α-subunit in mouse brain: Comparison ofPatch mutants and normal littermates
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Platelet-derived growth factor (PDGF) plays an important role not only in mesenchyme-derived tissues, but als...
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Nociceptive and thermoreceptive lamina I neurons are anatomically distinct
Pain and temperature stimuli activate neurons of lamina I within the dorsal horn of the spinal cord, and although these neurons can be classified into three basic morphological types and three major physiologi...
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Generation of oligodendroglial progenitors from neural stem cells
To understand how the differentiation of stem cells to oligodendroglial progenitors is regulated, we established cultures of neural stem cells from neonatal rat striatum in the presence of epidermal growth fac...
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Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition
The phenylethanolamines, ifenprodil and CP-101,606, are NMDA receptor antagonists with promising neuroprotective properties. In recombinant NMDA receptors expressed in Xenopus ...
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Regulation of morphological postsynaptic silent synapses in develo** hippocampal neurons
Many excitatory synapses are thought to be postsynaptically 'silent', possessing functional NMDA but lacking functional AMPA glutamate receptors. The acquisition of AMPA receptors at silent synap...
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SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
Peptides derived from proteolytic processing of the β–amyloid precursor protein (APP), including the amyloid–β peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice...
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Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1
Morphine produces analgesia by activating mu opioid receptors encoded by the MOR–1 gene. Although morphine–6β–glucuronide (M6G), heroin and 6–acetylmorphine also are considered mu opioids, recent evidence sugg...
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Analysis of potassium channel functions in mammalian axons by gene knockouts
Mammalian axons express a rich repertoire of various K channel subtypes whose distribution is profoundly affected by myelination. In the past two decades, functional analysis of axonal K channels has been appr...
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Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons
Primary sensory neurons serve a dual role as afferent neurons, conveying sensory information from the periphery to the central nervous system, and as efferent effectors mediating, e.g., neurogenic inflammation...
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Expression and regulation of NMDA receptor subunit R1 and neuronal nitric oxide synthase in cortical neuronal cultures: Correlation with cytochrome oxidase
Our previous studies showed a differential distribution of the glutamatergic terminals in cytochrome oxidase-rich and -poor regions of the visual cortex. The NMDA type of glutamate receptors have been proposed...
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A temporospatial map of adhesive molecules in the organ of corti of the mouse cochlea
In the nervous system, several classes of cell-surface and extracellular matrix molecules have been implicated in processes such as neural growth, fasciculation, pathfinding, target recognition and synaptogene...
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A comparison of synaptic protein localization in hippocampal mossy fiber terminals and neurosecretory endings of the neurohypophysis using the cryo-immunogold technique
In central synapses synaptic vesicle docking and exocytosis occurs at morphologically specialized sites (active zones) and requires the interaction of specific proteins in the formation of a SNARE complex. In ...
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Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease
Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed that conversion of...
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Visual input induces long-term potentiation of develo** retinotectal synapses
Early visual experience is essential in the refinement of develo** neural connections. In vivo whole-cell recording from the tectum of Xenopus tadpoles showed that repetitive dimming-light stimulation applied t...
