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  1. Article

    Open Access

    Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

    Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically and neuropathologically highly related α-synucleinopathies that collectively constitute the second leading cause of neurode...

    Balvindar Singh, Ana Covelo, Héctor Martell-Martínez… in Acta Neuropathologica (2019)

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    Actin at the Synapse: Contribution to Pre- and Postsynaptic Functions

    Synapses are specialized intercellular junctions through which one neuron sends signals to another neuron or a non-neuronal excitable cell. In the central nervous system (CNS), electrical signals can be propag...

    Dezhi Liao in Neurobiology of Actin (2011)

  3. Article

    Bidirectional Effects of Fentanyl on Dendritic Spines and AMPA Receptors Depend Upon the Internalization of Mu Opioid Receptors

    Fentanyl is a frequently used and abused opioid analgesic and can cause internalization of mu opioid receptors (MORs). Receptor internalization modulates the signaling pathways of opioid receptors. As changes ...

    Hang Lin, Paul Higgins, Horace H Loh, **-Yee Law, Dezhi Liao in Neuropsychopharmacology (2009)

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    Article

    Regulation of morphological postsynaptic silent synapses in develo** hippocampal neurons

    Many excitatory synapses are thought to be postsynaptically 'silent', possessing functional NMDA but lacking functional AMPA glutamate receptors. The acquisition of AMPA receptors at silent synap...

    Dezhi Liao, **aoqun Zhang, Richard O'Brien, Michael D. Ehlers… in Nature Neuroscience (1999)

  5. No Access

    Article

    Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

    LONG-TERM potentiation (LTP) is an enhancement of synaptic strength that can be produced by pairing of presynaptic activity with postsynaptic depolarization1. LTP in the hippocampus has been extensively studied a...

    Dezhi Liao, Neal A. Hessler, Roberto Malinow in Nature (1995)