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  1. Article

    Open Access

    Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells

    Nucleobase editors represent an emerging technology that enables precise single-base edits to the genomes of eukaryotic cells. Most nucleobase editors use deaminase domains that act upon single-stranded DNA an...

    Friedrich Fauser, Bhakti N. Kadam, Sebastian Arangundy-Franklin in Nature Communications (2024)

  2. Article

    Open Access

    Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems

    A crucial step towards engineering biological systems is the ability to precisely tune the genetic response to environmental stimuli. In the case of Escherichia coli inducible promoters, our incomplete understand...

    Timothy C. Yu, Winnie L. Liu, Marcia S. Brinck, Jessica E. Davis in Nature Communications (2021)