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Open AccessPrednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques
Adeno-associated virus (AAV) vector gene therapy is a promising approach to treat rare genetic diseases; however, an ongoing challenge is how to best modulate host immunity to improve transduction efficiency a...
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Article
Open AccessIntegrated vector genomes may contribute to long-term expression in primate liver after AAV administration
The development of liver-based adeno-associated virus (AAV) gene therapies is facing concerns about limited efficiency and durability of transgene expression. We evaluated nonhuman primates following intraveno...
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Article
Open AccessPotent antibody lineage against malaria transmission elicited by human vaccination with Pfs25
Transmission-blocking vaccines have the potential to be key contributors to malaria elimination. Such vaccines elicit antibodies that inhibit parasites during their development in Anopheles mosquitoes, thus break...
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Article
Engineering and expression of a RhoA peptide against respiratory syncytial virus infection in plants
A RhoA-derived peptide fused to carrier molecules from plants showed enhanced biological activity of in vitro assays against respiratory syncytial virus compared to the RhoA peptide alone or th...
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Article
Stabilization of HAC1 Influenza Vaccine by Spray Drying: Formulation Development and Process Scale-Up
Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process ...
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Open AccessPlant-produced transmission blocking Plasmodium falciparum Pfs25 subunit and VLP based vaccine candidates