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Open AccessEffects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study
Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions....
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Article
Open AccessBody mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study
Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and sym...
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Article
Open AccessBMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study
Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations i...
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Article
Open AccessMendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality
Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is lim...
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Article
Age at menarche and adult body mass index: a Mendelian randomization study
Pubertal timing has psychological and physical sequelae. While observational studies have demonstrated an association between age at menarche and adult body mass index (BMI), confounding makes it difficult to ...
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Article
Open AccessCorrecting for selection bias in two-stage trials with multiple correlated outcomes: application to seamless phase ii/iii clinical trials
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Open AccessPatient drift and response-adaptive randomisation: impact and solutions
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Open AccessType I error control in biomarker-stratified clinical trials
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Open AccessRevisiting the multi-armed bandit model for the optimal design of clinical trials: benefits and drawbacks
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Open AccessImpact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome
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Open AccessAdaptive enrichment in biomarker-stratified clinical trial design
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Open AccessImpact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome
In 2011, Royston et al. described technical details of a two-arm, multi-stage (TAMS) design. The design enables a trial to be stopped part-way through recruitment if the accumulating data suggests a lack of benef...
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Open AccessDesigning a preliminary adaptive study to inform a biomarker trial in Psoriasis