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Article
Metronomic chemotherapy plus anti-PD-1 in metastatic breast cancer: a Bayesian adaptive randomized phase 2 trial
It remains unclear whether metronomic chemotherapy is superior to conventional chemotherapy when combined with immune checkpoint blockade. Here we performed a phase 2 clinical trial of metronomic chemotherapy ...
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Article
Calculation and Correction Method of Dynamic Tire Loads in Accelerating and Braking Conditions
Accelerating performance and braking performance are the core performance of a vehicle, and tire load analysis is a prerequisite for performance studying. A calculation and correction method of dynamic tire lo...
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Article
Open AccessStabilizing atomic Ru species in conjugated sp2 carbon-linked covalent organic framework for acidic water oxidation
Suppressing the kinetically favorable lattice oxygen oxidation mechanism pathway and triggering the adsorbate evolution mechanism pathway at the expense of activity are the state-of-the-art strategies for Ru-b...
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Article
Liquid Phase Diffusion Analysis of WC–Co–Ni–Fe/HSS Composite Materials Based on DICTRA
Thermo-Calc and DICTRA software simulations were used to predict the feasibility of Co–Ni–Fe additives applied to WC/HSS composites, and WC–Co–Ni–Fe/HSS composites were prepared. The elemental diffusion behavi...
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Article
Comparative Study of the Microstructure and Mechanical Properties of WC/High-Speed Steel Composite Materials Prepared with Co, Ni, and Fe Binders
Three-mm-diameter WC/HSS composites with different binders (Co and Co-Ni-Fe) were prepared. The effect of two different binders on the microstructure and properties of WC powder and HSS composites was compared...
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Article
Open AccessIntegrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy
Protein inhibitor of activated STATs (PIAS) has pleiotropic biological effects, such as protein post-translational modification, transcriptional coregulation and gene editing. It is reported that PIAS family g...
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Article
Open AccessMesoporous carbon spheres with programmable interiors as efficient nanoreactors for H2O2 electrosynthesis
The nanoreactor holds great promise as it emulates the natural processes of living organisms to facilitate chemical reactions, offering immense potential in catalytic energy conversion owing to its unique stru...
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Article
Open AccessScalable integrated two-dimensional Fourier-transform spectrometry
Integrated spectrometers offer the advantages of small sizes and high portability, enabling new applications in industrial development and scientific research. Integrated Fourier-transform spectrometers (FTS) ...
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Article
BMSC-exosomes miR-25-3p Regulates the p53 Signaling Pathway Through PTEN to Inhibit Cell Apoptosis and Ameliorate Liver Ischemia‒reperfusion Injury
Hepatic ischemia‒reperfusion injury (HIRI) is a pathological phenomenon during liver surgery, and bone marrow-mesenchymal stem cell (BMSC) exosomes (BMSC-Exos) regulate cell apoptosis and reduce ischemia‒reper...
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Article
Open AccessSynthetic MRI in breast cancer: differentiating benign from malignant lesions and predicting immunohistochemical expression status
To evaluate and compare the performance of synthetic magnetic resonance imaging (SyMRI) in classifying benign and malignant breast lesions and predicting the expression status of immunohistochemistry (IHC) mar...
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Article
Screening and Identification of Probiotic Lactobacilli from the Infant Gut Microbiota to Alleviate Lead Toxicity
Lead (Pb2+) exposure cause a potential hazard to human health and the ecological environment; however, prevention and treatment of Pb2+ toxicity remain problems. The aim of this study is to isolate a novel probio...
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Article
Dynamic modeling of torsion bar spring suspension and sensitivity analysis of K&C characteristics
The torsion bar spring suspension has advantages of good dam** effect and simple structure, which make this type of suspension widely used. Suspension stiffness and wheel alignment parameters directly affect...
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Article
Open AccessBreaking the resolution-bandwidth limit of chip-scale spectrometry by harnessing a dispersion-engineered photonic molecule
The chip-scale integration of optical spectrometers may offer new opportunities for in situ bio-chemical analysis, remote sensing, and intelligent health care. The miniaturization of integrated spectrometers f...
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Article
Stiffness design and mechanical performance analysis of transverse leaf spring suspension
Suspension stiffness affects vehicle comfort and handling performance. The stiffness optimization of the transverse leaf spring suspension can be achieved by adjusting the distance between the two central inst...
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Article
Open AccessCoupling analysis and vibration control of vehicle vertical vibration and pitching vibration
The decoupling analysis of vertical vibration and pitching vibration is the basis of improving vehicle comfort performance and realizing vehicle body vibration control. In order to study the coupling behavior ...
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Article
Adhesive, sustained-release, antibacterial, cytocompatible hydrogel-based nanofiber membrane assembled from polysaccharide hydrogels and functionalized nanofibers
Hydrogels, three-dimensional hydrophilic polymer cross-linked networks, have attracted much attention in the fields of biomedicine, health care, etc., due to their unique water retention, and structural simila...
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Article
Ultrasound as a Non-thermal Pretreatment to Enhance Moisture Removal and Improve the Quality of French Fries
The impact of ultrasonic pretreatment on water loss, water mobility, microstructure, texture, volatile compounds, nutritional, and functional composition of French fries, and their intrinsic relationship, comp...
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Article
Open AccessS6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer
CDK4/6 inhibitors combined with endocrine therapy has become the preferred treatment approach for patients with estrogen receptor-positive metastatic breast cancer. However, the predictive biomarkers and mecha...
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Article
Open AccessClinical application of radiotherapy in patients with oligometastatic ovarian cancer: a sharp tool to prolong the interval of systemic treatment
With the advances of radiation technology, treatment of oligometastatic disease, with limited metastatic burden, have more chances to achieve long-term local control. Here we aim to evaluate the efficacy and s...
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Article
Life-cycle failure probability analysis of deteriorated RC bridges under multiple hazards of earthquakes and strong winds
Engineering structures may be exposed to one or more extreme hazards during their life-cycles. Current structural design specifications usually treat multiple hazards separately in designing structures and the...
