21 Result(s)

Article

In situ delivery of passive immunity by lactobacilli producing single-chain antibodies

Lactobacilli have previously been used to deliver vaccine components for active immunization in vivo. Vectors encoding a single-chain Fv (scFv) antibody fragment, which recognizes the streptococcal antigen I/II (...

Carina Krüger, Yanzhong Hu, Qiang Pan, Harold Marcotte… in Nature Biotechnology (2002)

Article

Lactobacillli expressing llama VHH fragments neutralise Lactococcusphages

Bacteriophages infecting lactic acid bacteria (LAB) are widely acknowledged as the main cause of milk fermentation failures. In this study, we describe the surface-expression as well as the secretion of two fu...

Anna Hultberg, Denise M Tremblay, Hans de Haard, Theo Verrips… in BMC Biotechnology (2007)

Article

Effective prophylaxis against rotavirus diarrhea using a combination of Lactobacillus rhamnosus GG and antibodies

Rotavirus is a worldwide cause of infectious infantile diarrhea that claims over 600,000 lives annually. Recently, two new vaccine candidates have been developed but their efficacy in develo** countries, sti...

Neha Pant, Harold Marcotte, Harald Brüssow, Lennart Svensson… in BMC Microbiology (2007)

Article

Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses

The primary objective of this study was to investigate if extended antibiotic treatment against bacterial vaginosis (BV) together with adjuvant lactobacilli treatment could cure BV and, furthermore, to investi...

Per-Göran Larsson, Erik Brandsborg, Urban Forsum… in BMC Infectious Diseases (2011)

Article

In situgastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli

Anthrax is caused by the bacterium Bacillus anthracis and is regarded as one of the most prominent bioterrorism threats. Anthrax toxicity is induced by the tripartite toxin complex, composed of the receptor-bindi...

Kasper Krogh Andersen, Harold Marcotte, Beatriz Álvarez… in BMC Biotechnology (2011)

Article

Identification and characterisation of vaginal lactobacilli from South African women

Bacterial vaginosis (BV), which is highly prevalent in the African population, is one of the most common vaginal syndromes affecting women in their reproductive age placing them at increased risk for sexually ...

Sonal Pendharkar, Tebogo Magopane, Per-Göran Larsson… in BMC Infectious Diseases (2013)

Article

Vaginal colonisation by probiotic lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection

The aim of this study was to investigate the colonisation by lactobacilli and clinical outcome in women with bacterial vaginosis (BV) and recurrent vulvovaginal candidiasis (R-VVC) receiving antibiotic or anti...

Sonal Pendharkar, Erik Brandsborg, Lennart Hammarström… in BMC Infectious Diseases (2015)

Article

Fusion of the mouse IgG1 Fc domain to the VHH fragment (ARP1) enhances protection in a mouse model of rotavirus

A variable fragment of a heavy chain antibody (VHH) directed against rotavirus, also referred to as anti-rotavirus protein 1 (ARP1), was shown to confer protection against rotavirus induced diarrhea in infant ...

Gökçe Günaydın, Shengze Yu, Torbjörn Gräslund, Lennart Hammarström… in Scientific Reports (2016)

Article

Lactobacillus delivery of bioactive interleukin-22

Interleukin-22 (IL-22) plays a prominent role in epithelial regeneration and dampening of chronic inflammatory responses by protecting intestinal stem cells from immune-mediated tissue damage. IL-22 has a cons...

Yin Lin, Kasper Krogh-Andersen, Lennart Hammarström… in Microbial Cell Factories (2017)

Article

An exploratory pilot study evaluating the supplementation of standard antibiotic therapy with probiotic lactobacilli in south African women with bacterial vaginosis

To reduce acquisition and relapse of bacterial vaginosis (BV), lactobacilli must be maintained in the vaginal microbiome. Probiotic lactobacilli may aid this purpose. We investigated whether vaginal probiotics...

Harold Marcotte, Per Göran Larsson, Kasper Krogh Andersen… in BMC Infectious Diseases (2019)

Article

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia

Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is in...

Hassan Abolhassani, Ahmad Vosughimotlagh, Takaki Asano… in Journal of Clinical Immunology (2022)

Article

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially mo...

Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine… in BMC Medicine (2022)

Article

Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome

Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in ch...

Hassan Abolhassani, Nils Landegren, Paul Bastard… in Journal of Clinical Immunology (2022)

Article

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies. Here we observed that an mRNA vaccine booster in individu...

Fanglei Zuo, Hassan Abolhassani, Likun Du, Antonio Piralla… in Nature Communications (2022)

Article

Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster

Harold Marcotte, Lennart Hammarström… in Signal Transduction and Targeted Therapy (2022)

Article

Design, structure and plasma binding of ancestral β-CoV scaffold antigens

We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patien...

David Hueting, Karen Schriever, Rui Sun, Stelios Vlachiotis… in Nature Communications (2023)