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Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Open AccessProteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins...
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Article
Open AccessIdentifying novel regulatory effects for clinically relevant genes through the study of the Greek population
Expression quantitative trait loci (eQTL) studies provide insights into regulatory mechanisms underlying disease risk. Expanding studies of gene regulation to underexplored populations and to medically relevan...
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Author Correction: The power of genetic diversity in genome-wide association studies of lipids
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Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Article
Open AccessDiscovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery d...
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Open AccessInsights into the genetic architecture of haematological traits from deep phenoty** and whole-genome sequencing for two Mediterranean isolated populations
Haematological traits are linked to cardiovascular, metabolic, infectious and immune disorders, as well as cancer. Here, we examine the role of genetic variation in sha** haematological traits in two isolate...
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Article
Open AccessMap** the serum proteome to neurological diseases using whole genome sequencing
Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic componen...
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Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00832-z.
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Article
Open AccessWhole-genome sequencing analysis of the cardiometabolic proteome
The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensivel...
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Open AccessThe transferability of lipid loci across African, Asian and European cohorts
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Gen...
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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessLow-frequency variation in TP53 has large effects on head circumference and intracranial volume
Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences sha** these traits dur...
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Open AccessAuthor Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
The original version of this Article contained an error in Fig. 2. In panel a, the two legend items “rare” and “common” were inadvertently swapped. This has been corrected in both the PDF and HTML versions of ...
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Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
In the version of the article published, the surname of author Aaron Isaacs is misspelled as Issacs.
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Open AccessEvidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia
The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using gen...
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Open AccessCohort-wide deep whole genome sequencing and the allelic architecture of complex traits
The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardio...
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Open AccessCombination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study
Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not yet b...
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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in...
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Article
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article.