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Article
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data
Osteoarthritis is the most common musculoskeletal disease and the leading cause of disability globally. Here, we performed a genome-wide association study for osteoarthritis (77,052 cases and 378,169 controls)...
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Article
Open AccessEvidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia
The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using gen...
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Article
Open AccessCombination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study
Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not yet b...
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Article
Open AccessGenome-wide association study of developmental dysplasia of the hip identifies an association with GDF5
Developmental dysplasia of the hip (DDH) is the most common skeletal developmental disease. However, its genetic architecture is poorly understood. We conduct the largest DDH genome-wide association study to d...
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Article
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biob...
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Article
Open AccessLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic i...
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Article
Open AccessGenetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants
Isolated populations are emerging as a powerful study design in the search for low-frequency and rare variant associations with complex phenotypes. Here we genotype 2,296 samples from two isolated Greek popula...
