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Article
Open AccessPrimary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN i...
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Article
Open AccessLessons for the clinical nephrologist: a rare case with MGRS characterized by combined crystalline light chain proximal tubulopathy and crystal-storing histiocytosis responding to daratumumab
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Article
Open AccessMyeloma cast nephropathy with diffuse amyloid casts without systemic amyloidosis: two cases report
Multiple myeloma (MM) is a plasma-cell derived hematologic malignant disease. The malignant proliferating plasma cells secrete massive monoclonal immunoglobulins which lead to various pathologic types of renal...
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Article
Open AccessTy** of hereditary renal amyloidosis presenting with isolated glomerular amyloid deposition
The commonly used methods for amyloid ty** include immunofluorescence or immunohistochemistry (IHC), which sometimes may come with diagnostic pitfalls. Mass spectrometry (MS)-based proteomics has been recogn...
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Article
Open AccessDelayed diagnosis of acromegaly in a patient with focal segmental Glomerulosclerosis: a rare case report and literature review
Experimental studies have demonstrated that hypersecretion of growth hormone (GH) is associated with development of glomerular sclerosis. However, clinical case of such condition is very rare. Here we presente...
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Article
Open AccessMembranoproliferative glomerulonephritis with deposition of monoclonal IgG evolved from polyclonal IgG: a case report with two consecutive renal biopsies
Proliferative glomerulonephritis with monoclonal Immunoglobulin (G) deposits (PGNMID) is a rare kind of MGRS with intact monoclonal IgG deposition. Seventy percent of PGNMID patients were negative for M-spike.
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Article
Open AccessMercury-associated glomerulonephritis: a retrospective study of 35 cases in a single Chinese center
Long-term exposure of mercury may induce glomerulonephritis. Clinical and pathological features of mercury-associated glomerulonephritis are not fully clear. This study retrospectively analyzed 35 cases of mer...
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Article
Open AccessMonoclonal light chain crystalline podocytopathy and tubulopathy associated with monoclonal gammopathy of renal significance: a case report and literature review
Monoclonal gammopathy of renal significance (MGRS) is a recently defined group of renal diseases caused by monoclonal immunoglobulin secreted by nonmalignant proliferative B cell or plasma cell. Monoclonal imm...
