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Article
Leaching Behaviors of Lithium-Rich Bauxite Flotation Tailings in Sodium Bicarbonate Solution
Multi-channel exploitation and utilization of lithium-bearing resources may be the future sustainable development trend of the lithium industry. Lithium-rich bauxite flotation tailings are a potential lithium ...
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Article
Non-coding RNAs: the new central dogma of cancer biology
The central dogma of molecular biology states that the functions of RNA revolve around protein translation. Until the last decade, most researches were geared towards characterization of RNAs as intermediaries...
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Article
siRNA therapeutics: a clinical reality
Since the revolutionary discovery of RNA interference (RNAi), a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism; especially in small interfering RNA (siRNA) thera...
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Article
Open AccessPhage display screening of therapeutic peptide for cancer targeting and therapy
Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixtu...
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Article
Open AccessSynthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers
Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle in the clinic, limiting its efficacy. However, the biological basis for intrinsic resistance is poorly understood. Here we perform...
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Article
Open AccessRBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma
Abnormal interaction between non-coding RNAs has been demonstrated to be a common molecular event in various human cancers, but its significance and underlying mechanisms have not been well documented. RNA-bin...
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Article
Selective enrichment of hepatocytes from mouse embryonic stem cells with a culture system containing cholestatic serum
There is increasing evidence indicating that embryonic stem (ES) cells are capable of differentiating into hepatocyte-like cells in vitro. However, it is necessary to improve the differentiation efficiency so as ...