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  1. No Access

    Article

    Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions

    A long-established strategy for transcription regulation is the tethering of transcription factors to cellular membranes. By contrast, the principal effectors of Hedgehog signalling, the GLI transcription fact...

    Farah Haque, Christian Freniere, Qiong Ye, Nandini Mani… in Nature Cell Biology (2022)

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    Article

    Reconstitution of the augmin complex provides insights into its architecture and function

    Proper microtubule nucleation during cell division requires augmin, a microtubule-associated hetero-octameric protein complex. In current models, augmin recruits γ-tubulin, through the carboxyl terminus of its...

    Kuo-Chiang Hsia, Elizabeth M. Wilson-Kubalek, Alejandro Dottore… in Nature Cell Biology (2014)

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    Article

    Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

    Hair cells of the inner ear are so-called because of the hair-like projections, or stereocilia, that protrude from their apical surface. Sound-induced stereocilial motion is thought to be coupled to mechanoele...

    Piotr Kazmierczak, Hirofumi Sakaguchi, Joshua Tokita, Elizabeth M. Wilson-Kubalek… in Nature (2007)

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    Article

    Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

    p97 (also called VCP), a member of the AAA ATPase family, is involved in several cellular processes, including membrane fusion and extraction of proteins from the endoplasmic reticulum for cytoplasmic degradat...

    Isabelle Rouiller, Byron DeLaBarre, Andrew P. May… in Nature Structural Biology (2002)

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    Article

    A structural change in the kinesin motor protein that drives motility

    Kinesin motors power many motile processes by converting ATP energy into unidirectional motion along microtubules. The force-generating and enzymatic properties of conventional kinesin have been extensively st...

    Sarah Rice, Abel W. Lin, Daniel Safer, Cynthia L. Hart, Nariman Naber… in Nature (1999)

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    Article

    A 32° tail swing in brush border myosin I on ADP release

    BRUSH border myosin I (BBMI) is a single-headed, unconventional myosin from intestinal microvilli, composed of a heavy chain of relative molecular mass 119,000 (Mr 119K) and three calmodulin light chains1–3. Alth...

    James D. Jontes, Elizabeth M. Wilson-Kubalek, Ronald A. Milligan in Nature (1995)

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    Article

    A 35-Å movement of smooth muscle myosin on ADP release

    MYOSIN II crossbridges interact with F-actin producing power-strokes of around 100 Å (refs 1, 2), during which the products of ATP hydrolysis are released3–5. This has been postulated to involve an articulation ...

    Michael Whittaker, Elizabeth M. Wilson-Kubalek, Joseph E. Smith, Lynn Faust… in Nature (1995)