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Article
Open AccessStructural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein
The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-β (Kap-β) in y...
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Article
Open AccessA synthetic pregnenolone analog promotes microtubule dynamics and neural development
Pregnenolone (P5) is a neurosteroid that promotes microtubule polymerization. It also reduces stress and negative symptoms of schizophrenia, promotes memory, as well as recovery from spinal cord injury. P5 is ...
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Article
Open AccessPhase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3
Many synaptic proteins form biological condensates via liquid-liquid phase separation (LLPS). Synaptopathy, a key feature of autism spectrum disorders (ASD), is likely relevant to the impaired phase separation...
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Article
Open AccessRan pathway-independent regulation of mitotic Golgi disassembly by Importin-α
To facilitate proper mitotic cell partitioning, the Golgi disassembles by suppressing vesicle fusion. However, the underlying mechanism has not been characterized previously. Here, we report a Ran pathway-inde...
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Article
Reconstitution of the augmin complex provides insights into its architecture and function
Proper microtubule nucleation during cell division requires augmin, a microtubule-associated hetero-octameric protein complex. In current models, augmin recruits γ-tubulin, through the carboxyl terminus of its...
