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  1. Article

    Open Access

    On the Q statistic with constant weights in meta-analysis of binary outcomes

    Cochran’s Q statistic is routinely used for testing heterogeneity in meta-analysis. Its expected value (under an incorrect null distribution) is part of several popular estimators of the between-study variance, ...

    Elena Kulinskaya, David C. Hoaglin in BMC Medical Research Methodology (2023)

  2. Article

    Open Access

    Dynamic meta-analysis: a method of using global evidence for local decision making

    Meta-analysis is often used to make generalisations across all available evidence at the global scale. But how can these global generalisations be used for evidence-based decision making at the local scale, if...

    Gorm E. Shackelford, Philip A. Martin, Amelia S. C. Hood, Alec P. Christie in BMC Biology (2021)

  3. Article

    Open Access

    Estimation in meta-analyses of response ratios

    For outcomes that studies report as the means in the treatment and control groups, some medical applications and nearly half of meta-analyses in ecology express the effect as the ratio of means (RoM), also cal...

    Ilyas Bakbergenuly, David C. Hoaglin, Elena Kulinskaya in BMC Medical Research Methodology (2020)

  4. Article

    Open Access

    Risk-adjusted CUSUM control charts for shared frailty survival models with application to hip replacement outcomes: a study using the NJR dataset

    Continuous monitoring of surgical outcomes after joint replacement is needed to detect which brands’ components have a higher than expected failure rate and are therefore no longer recommended to be used in su...

    Alexander Begun, Elena Kulinskaya in BMC Medical Research Methodology (2019)

  5. Article

    Open Access

    Meta-analysis of binary outcomes via generalized linear mixed models: a simulation study

    Systematic reviews and meta-analyses of binary outcomes are widespread in all areas of application. The odds ratio, in particular, is by far the most popular effect measure. However, the standard meta-analysis...

    Ilyas Bakbergenuly, Elena Kulinskaya in BMC Medical Research Methodology (2018)

  6. Article

    Open Access

    An accurate test for homogeneity of odds ratios based on Cochran’s Q-statistic

    A frequently used statistic for testing homogeneity in a meta-analysis of K independent studies is Cochran’s Q. For a standard test of homogeneity the Q statistic is referred to a chi-square distribution with K−1...

    Elena Kulinskaya, Michael B Dollinger in BMC Medical Research Methodology (2015)

  7. Article

    A Randomized, Double-Blind, Controlled Trial of the Effect of Prebiotic Oligosaccharides on Enteral Tolerance in Preterm Infants (ISRCTN77444690)

    Breast milk prebiotic oligosaccharides are believed to promote enteral tolerance. Many mothers delivering preterm are unable to provide sufficient milk. We conducted a multicenter, randomized, controlled trial...

    Neena Modi, Sabita Uthaya, John Fell, Elena Kulinskaya in Pediatric Research (2010)

  8. No Access

    Article

    Reliability testing of urodynamics, pressure flow studies and cough leak point pressure in women with urodynamic stress incontinence with and without detrusor overactivity

    Urodynamic studies which included cough leak point pressure (CLPP) and pressure flow studies were performed at two visits 2 weeks apart. Reproducibility between the two visits and also between the two diagnost...

    Philip Rahmanou, Charlotte Chaliha, Elena Kulinskaya in International Urogynecology Journal (2008)

  9. No Access

    Article

    Improvement in irritable bowel syndrome following ano-rectal surgery

    Background and aims: To assess the effect on irritable bowel syndrome (IBS) of treating ano-rectal problems by applying multiple Barron's bands to prolapsing mucosa and excising haemorrhoids, wit...

    Bernard V. Palmer, John W. Lockley in International Journal of Colorectal Disease (2002)

  10. Article

    Open Access

    Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.

    Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and acceptability of Sildenafil (Viagra) therapy in an unselec...

    Krishnamurthy Sairam, Elena Kulinskaya, Damian Hanbury, Gregory Boustead in BMC Urology (2002)