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Article
Opposition-based sine cosine optimizer utilizing refraction learning and variable neighborhood search for feature selection
This paper proposes new improved binary versions of the Sine Cosine Algorithm (SCA) for the Feature Selection (FS) problem. FS is an essential machine learning and data mining task of choosing a subset of high...
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Article
Open AccessCell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis
The ability of cells to manage consequences of exogenous proteotoxicity is key to cellular homeostasis. While a plethora of well-characterised machinery aids intracellular proteostasis, mechanisms involved in ...
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Article
Improved Salp swarm algorithm for solving single-objective continuous optimization problems
The Salp Swarm Algorithm (SSA) is an effective single-objective optimization algorithm that was inspired by the navigating and foraging behaviors of salps in their natural habitats. Although SSA was successful...
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Article
Open AccessDesigning a RESTful Northbound Interface for Incompatible Software Defined Network Controllers
In Software Defined Networking, applications often need to communicate with network controllers to query or modify the current state of the network. However, there is currently no standard northbound interface...
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Article
Island-based Cuckoo Search with elite opposition-based learning and multiple mutation methods for solving optimization problems
The island Cuckoo Search (iCSPM) algorithm is a variation of Cuckoo Search that uses the island model and highly disruptive polynomial mutation to solve optimization problems. This article introduces an improved
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Article
Open AccessConvergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation
Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are morphologically analogous to DMVs formed during autopha...
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Article
Healing Conversations: Develo** a Practical Framework for Clinical Communication Between Aboriginal Communities and Healthcare Practitioners
In recognition of the ongoing health disparities experienced by Aboriginal and Torres Strait Islander peoples (hereafter Aboriginal), this sco** review explores the role and impact of the clinical communicat...
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Article
Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus
We describe the expression of the hepatitis C virus nonstructural protein 4B (NS4B), which is an integral membrane protein, in a wheat germ cell-free system, the subsequent purification and characterization of...
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Article
Hepatitis C virus's next top models?
Advances in culturing hepatitis C virus have given hope for a universal cell culture system amenable to primary isolate replication. However, low replication efficiency needs to be overcome. The development of...
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Article
Cultural competence in medical education: aligning the formal, informal and hidden curricula
The concept of cultural competence has become reified by inclusion as an accreditation standard in the US and Canada, in New Zealand it is demanded through an Act of Parliament, and it pervades discussion in A...
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Article
Thyroid disease in children: part 2
Hyperthyroidism occurs secondary to overproduction of thyroid hormone by the thyroid gland. This condition can have rather serious effects on children, and thus timely diagnosis and treatment are of utmost imp...
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Article
The stability of cardiovascular reactivity: Effects of task-type and family history over a 3-year interval
Although there are now more than one-half dozen published studies examining the longitudinal stability of cardiovascular reactivity, methodological limitations leave several important issues unexplored. In thi...
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Article
Connexin 40-Deficient Mice Exhibit Atrioventricular Conduction Abnormalities and Ventricular Arrhythmias
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Article
Preparing for re-entry; A program for the sojourning student
A visitor to a new country is assaulted by many changes, both environmental and cultural. Expecting things to be different the visitor is shocked by what he/she finds, thus the term ‘culture shock’. A second s...
