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  1. No Access

    Article

    Water relations and mechanical properties of growing cells

    E. Steudle, D. Cosgrove in Biophysics of structure and mechanism (1980)

  2. No Access

    Article

    Long-term acid-induced wall extension in an in-vitro system

    When frozen-thawed Avena sativa L. coleoptile and Cucumis sativa L. hypocotyl sections, under tension, are acid-treated, they undergo rapid elongation (acid-extension). The acid-extension response consists of two...

    R. E. Cleland, D. Cosgrove, M. Tepfer in Planta (1987)

  3. No Access

    Article

    A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer

    Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared...

    TJ Powles, JR Hardy, SE Ashley, GM Farrington, D Cosgrove… in British Journal of Cancer (1989)

  4. No Access

    Article

    The Royal Marsden Hospital pilot tamoxifen chemoprevention trial

    A pilot randomised placebo controlled trial using tamoxifen in healthy women at increased risk of develo** breast cancer, has been undertaken in order to evaluate the problems of accrual, acute symptomatic t...

    T. J. Powles, A. L. Jones, S. E. Ashley… in Breast Cancer Research and Treatment (1994)

  5. No Access

    Article

    Microbubble enhancement of tumour neovascularity

    D. Cosgrove in European Radiology (1999)

  6. No Access

    Article

    The breast

    D. Cosgrove in European Radiology (1999)

  7. No Access

    Article

    Liver-specific imaging with SHU 563A: Diagnostic potential of a new class of ultrasound contrast media

    The purpose of this study was to evaluate the imaging properties and diagnostic potential of the novel polymeric ultrasound contrast agent SHU 563 A. After i. v. injection, the agent circulates in the blood p...

    A. Bauer, M. Blomley, E. Leen, D. Cosgrove, R. Schlief in European Radiology (1999)

  8. Article

    Inflammatory arthritis, hypoxia and vascularity

    PC Taylor, A Steuer, P Etherington, D Cosgrove, RN Maini in Arthritis Research & Therapy (2001)

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  9. Article

    TNF-α blockade in early rheumatoid significantly reduces serum VEGF and ultrasonographic measures of synovitis and joint vascularity by 18 weeks

    PC Taylor, A Steuer, P Charles, J Gruber, D Cosgrove… in Arthritis Research & Therapy (2002)

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  10. No Access

    Article

    Liver tumors

    The development and clinical introduction of microbubble contrast agents has had a particular impact on the detection and differential diagnosis of liver tumors. The first approach widely employed made use of ...

    D. Cosgrove, M. Blomley in Abdominal Imaging (2004)

  11. No Access

    Article

    THEMIS Operations

    THEMIS—a five-spacecraft constellation to study magnetospheric events leading to auroral outbursts—launched on February 17, 2007. All aspects of operations are conducted at the Mission Operations Center at the...

    M. Bester, M. Lewis, B. Roberts, J. McDonald, D. Pease… in Space Science Reviews (2008)

  12. No Access

    Article

    Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome

    Response to immunosuppressive therapy (IST) in younger patients with myelodysplastic syndrome (MDS) has been linked to a T-cell-dominant autoimmune process that impairs hematopoiesis. Analysis of the age-adjus...

    J X Zou, D E Rollison, D Boulware, D-T Chen, E M Sloand, L V Pfannes… in Leukemia (2009)

  13. Article

    Open Access

    A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours

    We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selumetinib (MEK 1/2 inhibitor).

    B A Wilky, M A Rudek, S Ahmed, D A Laheru, D Cosgrove… in British Journal of Cancer (2015)

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  14. Article

    Open Access

    Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

    Mipsagargin (G-202; (8-O-(12-aminododecanoyl)-8-O-debutanoyl thapsigargin)-Asp-γ-Glu-γ-Glu-γ-GluGluOH)) is a novel thapsigargin-based targeted prodrug that is activated by PSMA-mediated cleavage of an inert maski...

    D Mahalingam, G Wilding, S Denmeade, J Sarantopoulas… in British Journal of Cancer (2016)

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  15. Article

    Open Access

    MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls

    Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive performance. As microRNA-137 is known to regulate the ...

    D Cosgrove, D Harold, O Mothersill, R Anney, M J Hill, N J Bray… in Translational Psychiatry (2017)

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  16. Article

    Open Access

    Comparing accelerometer, pedometer and a questionnaire for measuring physical activity in bronchiectasis: a validity and feasibility study

    There are challenges for researchers and clinicians to select the most appropriate physical activity tool, and a balance between precision and feasibility is needed. Currently it is unclear which physical acti...

    B. O’Neill, S. M. McDonough, J. J. Wilson, I. Bradbury, K. Hayes… in Respiratory Research (2017)

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  17. No Access

    Article

    Variability in circulating gas emboli after a same scuba diving exposure

    A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which ...

    V. Papadopoulou, P. Germonpré, D. Cosgrove… in European Journal of Applied Physiology (2018)