8 Result(s)
within
Article
Chih Long Liu
English
-
Article
Open AccessQuantification of cerebrospinal fluid tumor DNA in lung cancer patients with suspected leptomeningeal carcinomatosis
Cerebrospinal fluid tumor-derived DNA (CSF-tDNA) analysis is a promising approach for monitoring the neoplastic processes of the central nervous system. We applied a lung cancer-specific sequencing panel (CAPP...
-
Article
Predicting HLA class II antigen presentation through integrated deep learning
Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules would be valuable for vaccine development and cancer immunotherapies. Current computational methods trained on in...
-
Article
Open AccessData normalization considerations for digital tumor dissection
In a recently published article in Genome Biology, Li and colleagues introduced TIMER, a gene expression deconvolution approach for studying tumor-infiltrating leukocytes (TILs) in 23 cancer types profiled by The...
-
Article
Open AccessSpecific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies
Autoreactivity to histones is a pervasive feature of several human autoimmune disorders, including systemic lupus erythematosus (SLE). Specific post-translational modifications (PTMs) of histones within neutro...
-
Article
Open AccessA proteomic approach for the identification of novel lysine methyltransferase substrates
Signaling via protein lysine methylation has been proposed to play a central role in the regulation of many physiologic and pathologic programs. In contrast to other post-translational modifications such as ph...
-
Article
Open AccessRNA polymerase map** during stress responses reveals widespread nonproductive transcription in yeast
The use of genome-wide RNA abundance profiling by microarrays and deep sequencing has spurred a revolution in our understanding of transcriptional control. However, changes in mRNA abundance reflect the combin...
-
Article
Open AccessGlobal nucleosome occupancy in yeast
Although eukaryotic genomes are generally thought to be entirely chromatin-associated, the activated PHO5 promoter in yeast is largely devoid of nucleosomes. We systematically evaluated nucleosome occupancy in ye...
-
Article
Open AccessDevelopment and validation of a T7 based linear amplification for genomic DNA
Genomic maps of transcription factor binding sites and histone modification patterns provide unique insight into the nature of gene regulatory networks and chromatin structure. These systematic studies use mic...
