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Article
The cyclobutane dimers of 5-methylcytosine and their deamination products
The photochemical reactions of 5-methylcytosine (m5C), a minor component of mammalian DNA, have been studied at a concentration of 2 mM in frozen 10 mM aqueous NaCl solution at dry ice temperature (194.5 K). For ...
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Article
Conformational dynamics in mixed α/β-oligonucleotides containing polarity reversals: A molecular dynamics study using time-averaged restraints*
Nucleic acid duplexes featuring a single alpha-anomeric thymidine inserted into each DNA strand via 3′-3′ and 5′-5′ phosphodiester linkages exhibit local conformational dynamics that are not adequately depicte...
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Article
Contributory presentations/posters
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Article
Structure of the dimer a initiation complex of HIV-1 genomic RNA
Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through th...
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Article
A 500 MHz proton NMR study of the interaction of the tripeptide Lys-Tyr-Lys with the tetradeoxynucleotides d-CpCpGpG and d-CpGpCpG
Two dimensional proton NMR experiments at 500 MHz show that d-CpCpGpG exists as a right handed B-DNA structure in D2O solution with both sugars in O1' endo and glycosidic bond angle in anticonformation. On comple...