12 Result(s)
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Article
Anna Schmitt
English
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Article
Intensive chemotherapy followed by autologous stem cell transplantation in primary central nervous system lymphomas (PCNSLs). Therapeutic outcomes in real life—experience of the French Network
We analysed the therapeutic outcomes of all consecutive patients with primary central nervous system lymphoma (PCNSL) registered in the prospective French database for PCNSL and treated with intensive chemothe...
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Carfilzomib maintenance in newly diagnosed non-transplant eligible multiple myeloma
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Open AccessDifferential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells
Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune ...
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Open AccessFerroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
Loss of TP53 and RB1 in treatment-naïve small cell lung cancer (SCLC) suggests selective pressure to inactivate cell death pathways prior to therapy. Yet, which of these pathways remain available in treatment-naï...
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Open AccessmTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alt...
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Decreasing stand density favors resistance, resilience, and recovery of Quercus petraea trees to a severe drought, particularly on dry sites
Decreasing stand density increases resistance, resilience, and recovery of Quercus petraea trees to severe drought (2003), particularly on dry sites, and the...
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ATM activity in T cells is critical for immune surveillance of lymphoma in vivo
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer pre...
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Open AccessMYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
MYC paralogs are frequently activated in small cell lung cancer (SCLC) but represent poor drug targets. Thus, a detailed map** of MYC-paralog-specific vulnerabilities may help to develop effective therapies for...
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Open AccessOvercoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
The emergence of acquired resistance against targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. In a subgroup of these patients we identified an association between selection of EG...
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AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer
A fundamental principle in malignant tranformation is the ability of cancer cells to escape the naturally occurring cell-intrinsic responses to DNA damage. Tumors progress despite the accumulation of DNA lesio...
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Open AccessClonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of ei...
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Open AccessTargeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer
Small cell lung cancer (SCLC) is a difficult to treat subtype of lung cancer. One of the hallmarks of SCLC is its almost uniform chemotherapy sensitivity. However, chemotherapy response is typically transient ...
