256 Result(s)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Dietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study

Yujie Xu, **gyuan **ong, **aoyu Wang, Fang He… in Signal Transduction and Targeted Therapy (2024)

Article

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-rea...

**n Wang, Jie Zhang, Maoshun Liu, Yuanyuan Guo… in Signal Transduction and Targeted Therapy (2024)

Article

Molecular landscape and multi-omic measurements of heterogeneity in fetal adenocarcinoma of the lung

Fetal adenocarcinoma of the lung (FLAC) is a rare form of lung adenocarcinoma and was divided into high-grade (H-FLAC) and low-grade (L-FLAC) subtypes. Despite the existence of some small case series studies, ...

Li Sun, Wei Guo, Lei Guo, **aoxi Chen, Haitao Zhou, Shi Yan… in npj Precision Oncology (2024)

Article

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor efficacy. Targeted radionuclide therapy delivers radiation directly to tumor sites. LNC1004 is a fibroblast a...

Liang Zhao, Yizhen Pang, Yangfan Zhou… in Signal Transduction and Targeted Therapy (2024)

Article

8-Cl-Ado and 8-NH₂-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia

Targeting the metabolic dependencies of acute myeloid leukemia (AML) cells is a promising therapeutical strategy. In particular, the cysteine and methionine metabolism pathway (C/M) is significantly altered in...

Jiamin Guo, Ralf Buettner, Li Du, Zhenlong Li, Wei Liu, Rui Su, Zhenhua Chen… in Leukemia (2024)

Article

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...

Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan… in Signal Transduction and Targeted Therapy (2024)

Article

Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer

The proto-oncogene MYC encodes a nuclear transcription factor that has an important role in a variety of cellular processes, such as cell cycle progression, proliferation, metabolism, adhesion, apoptosis, and ...

Thomas F. Cyberski, Alka Singh, Michael Korzinkin, Vasudha Mishra… in npj Precision Oncology (2024)

Article

Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study

The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 eld...

Hong-Hong Liu, Yunbo **e, Bao-Peng Yang… in Signal Transduction and Targeted Therapy (2024)

Article

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it diff...

Rao Fu, Ruoyao Qi, Hualong **ong, **ng Lei… in Signal Transduction and Targeted Therapy (2024)

Article

The Eμ-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia

The presence of supernumerary chromosomes is the only abnormality shared by all patients diagnosed with high-hyperdiploid B cell acute lymphoblastic leukemia (HD-ALL). Despite being the most frequently diagnos...

Ali Farrokhi, Tanmaya Atre, Jenna Rever, Mario Fidanza, Wendy Duey… in Leukemia (2024)

Article

Scientific figures interpreted by ChatGPT: strengths in plot recognition and limits in color perception

Emerging studies underscore the promising capabilities of large language model-based chatbots in conducting basic bioinformatics data analyses. The recent feature of accepting image inputs by ChatGPT, also kno...

**ge Wang, Qing Ye, Li Liu, Nancy Lan Guo, Gangqing Hu in npj Precision Oncology (2024)

Article

Tumor heterogeneity and clinically invisible micrometastases in metastatic breast cancer—a call for enhanced surveillance strategies

The biology of metastatic breast cancer (MBC) is understudied, primarily due to the difficulty of procuring multiple samples from patients with oligometastatic breast cancer. We developed a rapid postmortem ti...

Eliza R. Bacon, Kena Ihle, Weihua Guo, Colt A. Egelston… in npj Precision Oncology (2024)

Article

First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study

Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apati...

**aofeng Chen, Hao Xu, **aobing Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore effective and safe treatment for newly diagnosed advanced stage...

Jie **ong, Shu Cheng, **ao Gao, Shan-He Yu… in Signal Transduction and Targeted Therapy (2024)

Article

NF-κB in biology and targeted therapy: new insights and translational implications

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations,...

Qing Guo, Yizi **, **nyu Chen, **aomin Ye… in Signal Transduction and Targeted Therapy (2024)

Article

Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes

Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key en...

Qing Zhang, Mengen **ng, Zhengkai Bao, Lu Xu… in Signal Transduction and Targeted Therapy (2024)