4,326 Result(s)
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Article
Antibody Formation and Experimentally Induced Chimerism in Very Young Rabbits
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Capacity of Pepsin-digested Antibody to inhibit Antibody Formation
THE capacity of passively administered serum antibody to inhibit specific antibody formation1 has suggested that serum antibody may act as a type of “feedback” mechanism2–5. It is not known whether this effect of...
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Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro
WHOLE body X-irradiation depresses or enhances the antibody response depending on the dosage and its temporal relationship to injection of antigen in the animal1. Using organ cultures of rabbit lymph nodes, we su...
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Altered erythrocyte membrane phosphorylation in sickle cell disease
FOR several years evidence has been accumulating to indicate that the erythrocytes of individuals with sickle cell anaemia not only contain an abnormal haemoglobin but also exhibit several altered membrane cha...
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Non-metastasising variants selected from metastasising melanoma cells
THE cell surface may be involved in the metastatic process of cancer cells1. To determine whether membrane properties influence or reflect the metastasising capacity, it is essential to have metastasising and non...
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Inhibition of mutant troponin C activity by an intra-domain disulphide bond
Triggering of contraction in striated muscles involves a conformational transition in the N-terminal domain of troponin C, the calcium-binding component of thin filaments. We have designed a mutant troponin C ...
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Manufacture of bulk superconducting YBa2Cu3O7-δ by a continuous process
THE high critical current densities (Jcs) measured in thin films and within grains of the high-transition-temperature (high-MTc) oxide superconductors indicate that low Jc should not prevent the use of high-Tc ma...
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Article
A small metalloribozyme with a two-step mechanism
An RNA molecule consisting of an asymmetric internal loop of six nucleotides can be rapidly and specifically cleaved by Pb2+ in the presence of Mg2+. The 5′ cleavage product terminates with a 3′ phosphomonoester ...
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Deformation of a weak subducted slab and variation of seismicity with depth
OCEANIC lithosphere is assumed to possess platelike properties whether it is lying at the Earth's surface or descending deep into the mantle; yet the geometries of subducting slabs indicate significant deforma...
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Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma
TO produce a vaccine against cancer, antigens must be found that are preferentially expressed by tumour cells and can induce an immune response against the tumour. The variable regions of the immunoglobulin mo...
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A diverse new primate fauna from middle Eocene fissure-fillings in southeastern China
We report the discovery of a fauna of primates from Eocene (˜45 Myr) deposits in China having a diversity greater than in European and North American localities of similar antiquity. From the many forms that ...
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Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
A NUMBER of DNA viruses carry apoptosis-inhibiting genes which enable the virus to escape from the host reponse1–5. The adenovirus E1B 19K protein can inhibit apoptosis induced by El A, tumour-necrosis factor-α, ...
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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
INHIBITORS of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse transcriptase inhi...
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Spontaneous resistance to acute T-cell leukaemias in TCRVγ1.1Jγ4Cγ4 transgenic mice
THE concept of tumour surveillance implies that specific and nonspecific components of the immune system eliminate tumours in the early phase of malignancy1,2. The immunological mechanisms that control growth of ...
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A death-domain-containing receptor that mediates apoptosis
THE cell-killing effects of the cytokines TNF-α and FasL are mediated by the distinct cell-surface receptors TNFR1, TNFR2 and Fas (also known as CD95/APO-1), which are all members of a receptor superfamily tha...
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Convergent total synthesis of a tumour-associated mucin motif
Synthetic glycoconjugates that mimic cell-surface tumour antigens (glycolipids or glycoproteins with unusual carbohydrate structural motifs) have been shown to trigger humoral responses in murine and human imm...
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Synthesis of microporous transition-metal-oxide molecular sieves by a supramolecular templating mechanism
Mesoporous bulk1,2,3,4 and thin-film5,6,7 silicates with pore sizes of 20–100 Å can be synthesized by using micellar aggregates of long-chain organic surfactant molecules as templates to direct the structure of t...
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Ultradry seed storage cuts cost of gene bank
Today we are faced with an urgent challenge to organize the efficient conservation of biodiversity. In the case of plants, one way of doing this is to store their seeds in a gene bank. The effective preservati...
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A critical window for cooperation and competition among develo** retinotectal synapses
In the develo** frog visual system, topographic refinement of the retinotectal projection depends on electrical activity. In vivo whole-cell recording from develo** Xenopus tectal neurons shows that convergen...
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Heparin is essential for the storage of specific granule proteases in mast cells
All mammals produce heparin, a negatively charged glycosaminoglycan that is a major constituent of the secretory granules of mast cells which are found in the peritoneal cavity and most connective tissues. Alt...
