631 Result(s)

Article

Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas

The clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale, population-based study aimed to comprehensively outline these traits and construct ...

Tao Chang, Rui Zhang, Jiahao Gan, Yuan Yang, Yanhui Liu, Yan Ju, **aodong Niu… in BMC Cancer (2024)

Article

Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds

The global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects on various tissues within the human body. Among these tissues, skeletal muscl...

Lauren Jun, Ya-**ong Tao, Thangiah Geetha… in Current Nutrition Reports (2024)

Article

Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4

The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development and antitumor acti...

Jianyao Zeng, Yuan Fang, Zixuan Zhang, Zhenzhen Lv, **aodie Wang, Qian Huang… in Oncogene (2024)

Article

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

Cancer, a prevalent and complex disease, presents a significant challenge to the medical community. It is characterized by irregular cell differentiation, excessive proliferation, uncontrolled growth, invasion...

Haihong Lin, Jun Zhou, Tao Ding, Yifan Zhu… in European Journal of Medical Research (2024)

Article

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...

Yuzheng Zhou, Zongpeng Chen, Sijie Liu… in Signal Transduction and Targeted Therapy (2024)

Article

CACA guidelines for holistic integrative management of anticancer treatment - induced cutaneous adverse events

The skin and mucous membrane of cancer patients can be directly or indirectly impaired during the treatment of cancers, bringing about not physical but also psychological damages to cancer patients. A practica...

Guannan Zhu, Qiong Shi, Tao Cai, Dongcheng Gu, Hang Zhou… in Holistic Integrative Oncology (2024)

Article

Screening of potential hub genes involved in Kidney Wilms tumor via bioinformatics analysis and experimental validation

Wilms tumor (WT) is the most common pediatric embryonal tumor. Improving patient outcomes requires advances in understanding and targeting the multiple genes and cellular control pathways, but its pathogenesis...

Qiang Zeng, Tingting Liu, Lilu Qin, Chen Wang, Guangbei Peng, Zhong Liu… in BMC Cancer (2024)

Article

Suspected myometrial invasion on MRI is correlated with worse outcomes of fertility-preserving treatment in young women with endometrial cancer

Myometrial invasion of endometrial cancer (EC) impairs the effectiveness of progestin-based treatment and results in high risks of disease progression and relapse. However, it is difficult to decide whether my...

Chengcheng Ning, Zhiying Xu, Fenghua Ma, Qin Zhu… in Holistic Integrative Oncology (2024)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

Transcriptional dysregulation and insights into clinical implications in melanoma

Melanoma, a highly prevalent cancer worldwide, exhibits remarkable diversity and plasticity, with the adverse prognosis of advanced melanoma remaining a focal point of investigation. Despite the emergence of n...

Chen Shen, Mengjiao Chen, Xuanbingning Nian, Jun Li… in Holistic Integrative Oncology (2024)

Article

Correlation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis

The role of hemoglobin (HGB) in common malignant tumors remains unclear.

Guo-Sheng Li, Tao Huang, **g-**ao Li, Jun Liu, **ang Gao, Nuo Yang… in BMC Cancer (2024)

Article

DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severi...

Jun Chen, Tao Wang, **aoou Li, Lijuan Gao… in Signal Transduction and Targeted Therapy (2024)

Article

TACE combined Lenvatinib plus Camrelizumab versus TACE alone in efficacy and safety for unresectable hepatocellular carcinoma: a propensity score-matching study

To compare the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined Lenvatinib plus Camrelizumab (TLC) in unresectable hepatocellular carcinoma (uHCC) with those of TACE alone .

Zhihong Tang, Tao Bai, Tao Wei, **aobo Wang, Jie Chen, Jiazhou Ye, Shangqi Li… in BMC Cancer (2024)

Article

Correction: O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination

Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, **n Wan… in Oncogene (2024)

Article

Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer

Ovarian cancer is one of the most common gynecological malignant tumors with insidious onset, strong invasiveness, and poor prognosis. Metabolic alteration, particularly aerobic glycolysis, which is tightly re...

Cancan Zhang, Yinyin Xu, **nyue Zhu, Xueli Zhang, Fengmian Wang, Lipeng Hu… in Oncogene (2024)

Article

P4HA2 activates mTOR via hydroxylation and targeting P4HA2-mTOR inhibits lung adenocarcinoma cell growth

Mammalian target of rapamycin (mTOR) kinase functions as a central regulator of cell growth and metabolism, and its complexes mTORC1 and mTORC2 phosphorylate distinct substrates. Dysregulation of mTOR signalin...

Ersuo **, Shengjie Wang, Donglai Chen, Jia-** Wang, Yuanyuan Zeng… in Oncogene (2024)

Article

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study

The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate. Hence, the objective of ...

**shuai Li, Zixian Yang, Tao Wang, Mengqi Li, **angjian Wu, **aoyan Fu… in BMC Cancer (2024)

Article

Clinical application of serum tumor abnormal protein in prostate cancer patients

To explore the clinical value of tumor abnormal protein (TAP) in the diagnosis and prognosis evaluation of prostate cancer.

Liusong Fu, Chi Zhang, Zewen Wang, Wei Tao, ** Zhu, Yibin Zhou… in BMC Cancer (2024)

Article

MIIP downregulates PD-L1 expression through HDAC6 in cutaneous melanoma

Immune checkpoint inhibitors have improved the objective response rate and survival of melanoma patients. However, there are still many melanoma patients suffering from disease progression due to primary or se...

Ting Li, Ruwei **ng, Lijie **ang, Haotian Liu… in Holistic Integrative Oncology (2024)

Article

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain uncl...

Gang Yang, **peng Cao, Jian Qin, **nyue Mei… in Signal Transduction and Targeted Therapy (2024)