247 Result(s)
within
Biomedicine
Neurochemistry
Neurosciences
**u Tao
Article
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Article
A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin
We report the identification of a full-length novel β-spectrin II gene (βSpIIΣ2) in human brain. The βSpIIΣ2 gene has 32 exons encoding an actin-binding domain, followed by 17-spectrin repeats, and a short COO...
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Triptolide Upregulates NGF Synthesis in Rat Astrocyte Cultures
Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by d-amphetamine and prevent the loss of dopaminer...
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ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells
ADAM23, belonging to ADAM (A Disintegrin And Metalloprotease) protein family, is mainly expressed in brain. P19 cells could differentiate into neuroectodermal cell lineage after cell aggregates have been induc...
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Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats
Status epilepticus (SE) is associated with a significant risk of cognitive impairment, and the increase of nitric oxide (NO) releasing has been reported during SE. We investigated the effects of neuronal nitri...
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In vitro Methionine5-Enkephalin Degradation Kinetics by Human Brain Preparations
Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid a...
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Rapid Decrease of GAD 67 Content Before the Convulsion Induced by Hyperbaric Oxygen Exposure
Exposure to hyperbaric oxygen (HBO) can lead to seizures, the etiology of which is not completely understood. Glutamic acid decarboxylase (GAD) plays a very important role in maintaining excitatory-inhibitory ...
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Transplantation of NGF-Gene-Modified Bone Marrow Stromal Cells into a Rat Model of Alzheimer’ Disease
It is well known that bone marrow stromal cells (BMSC) grafted into the hippocampus of the rat model of Alzheimer’s disease (AD) could survive and differentiate into cholinergic neurons as well as contribute t...
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Association of NAD(P)H:Quinone Oxidoreductase 1 Polymorphism and Alzheimer’s Disease in Chinese
Several lines of evidence support a role of oxidative stress in the pathology of Alzheimer’s disease (AD). NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing t...
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Transplantation of NGF-Gene-Modified Bone Marrow Stromal Cells into a Rat Model of Alzheimer’ Disease
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The Role of Hypoxia in the Differentiation of P19 Embryonal Carcinoma Cells into Dopaminergic Neurons
Nervous system development at early stage is in hypoxic environment. Very little is known about the role of hypoxia in neuronal development. P19 embryonal carcinoma (EC) cells are a widely used model for study...
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Searching for Molecular Players Differentially Involved in Neurotransmitter and Neuropeptide Release
Neurotransmitters and neuropeptides are stored in small clear vesicles (SCVs) and large dense core vesicles (LDCVs), respectively. Many differences in the properties of SCVs and LDCVs suggest that these two cl...
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Effects of Acrylamide on the Nervous Tissue Antioxidant System and Sciatic Nerve Electrophysiology in the Rat
To investigate the time-dependent effects of acrylamide (ACR) on the antioxidative status in rat nerve tissues, adult male Wistar rats were given ACR (40 mg/kg, i.p., 3 times/week) for 2, 4, 6 and 10 weeks, re...
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Role of Mitogen-Activated Protein Kinase Cascades in Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide in a Rat Schwann Cell Line
It is well known that the mitogen-activated protein kinase (MAPK) signal transduction pathways is involved in the regulation of inducible nitric oxide synthase (iNOS) in many cellular systems. However, suffici...
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Nestin in the Temporal Neocortex of the Intractable Epilepsy Patients
Nestin is one kind of intermediate filament protein, which is considered as a typical marker of neural precursor cells. Considerable evidence supports nestin may have actively functions in neurogenesis and gli...
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Lipid Peroxidation was Involved in the Memory Impairment of Carbon Monoxide-induced Delayed Neuron Damage
Carbon monoxide (CO)-induced delayed neuron damage is the serious complication, but the underlying mechanisms are poorly understood. This study was designed to investigate the time-dependent changes of the lip...
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Up-Regulation of Epithelial Membrane Protein-1 in the Temporal Neocortex of Patients with Intractable Epilepsy
Epithelial membrane protein-1 (EMP-1), called Tumor-associated membrane protein, is the marker of a drug-resistant tumor and take part in the drug-resistant mechanism of tumor, with the relationship of epiderm...
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SSeCKS is a Suppressor in Schwann Cell Differentiation and Myelination
Src-suppressed protein kinase C substrate (SSeCKS) plays an important role in the differentiation process. In regeneration of sciatic nerve injury, expression of SSeCKS decreases, mainly in Schwann cells. Howe...
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The Restoration After Repetitive Transcranial Magnetic Stimulation Treatment on Cognitive Ability of Vascular Dementia Rats and Its Impacts on Synaptic Plasticity in Hippocampal CA1 Area
The purposes of this research were to study the restoration on the cognitive ability of rat models with vascular dementia (VaD) by repetitive transcranial magnetic stimulation (rTMS) treatment and its impacts ...
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Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy
The small guanosine triphosphatase RhoA has recently been implicated in the pathogenesis of epilepsy in animals. In this study, we investigated the expression of RhoA in human epilepsy. Brain tissue samples fr...
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Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia
The expression of the N-methyl-D-aspartate receptor (NMDA-R) in astrocytes is controversial. The receptor is commonly considered neuron-specific. We showed that astrocytes in primary cultures differentially expre...
