-
Article
Open AccessAn epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
Despite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide1. Non-small cell lung cancer (NSCLC) patients have a very poor overall five-year survival rate of ...
-
Article
Open AccessBNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia
Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting p...
-
Article
Open AccessExploration and characterization of the memcapacitor and memristor properties of Ni–DNA nanowire devices
A 2-μm-long Ni ion-chelated DNA molecule (Ni–DNA) was found for the first time to possess both memcapacitor and memristor properties; this Ni–DNA molecule is known as a dual memory circuit element (memelement)...
-
Article
Open AccessmiR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha
The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is ...
-
Article
Flavone Di-C-Glycosides from Selaginella uncinata and Their Antioxidative Activities
-
Article
Open AccessMethylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy
The treatment of stroke is limited by a short therapeutic window and a lack of effective clinical drugs. Methylene blue (MB) has been used in laboratories and clinics since the 1890s. Few studies have reported...
-
Article
Ring-opening copolymerization of cyclohexene oxide and maleic anhydride catalyzed by mononuclear [Zn(L)(H2O)] or binuclear [Zn2(L)(OAc)2(H2O)] complex based on the Salen-type Schiff-base ligand
From the self-assembly of the typical Salen-type Schiff-base ligand H 2 L and Zn(OAc)2·2H2O in the molar ratio of 1:1 or 1:2, the mononuclear [Z...
-
Article
γ-Lactone Derivatives and Terpenoids from Selaginella uncinata and Their Protective Effect Against Anoxia
-
Chapter
Perishing Confucius
Like many other Higher Education (HE) sectors around the world (see, for example, Deem & Brehony, 2005; Dominelli & Hoogvelt, 1996; Hayes & Wynyard, 2002; Jary & Parker, 1998; Leung, 2007; Nkomo, 2009; Strathe...
-
Article
Open AccessEnhanced Hypoxia-Inducible Factor (HIF)-1α Stability Induced by 5-Hydroxymethyl-2-Furfural (5-HMF) Contributes to Protection against Hypoxia
We first reported the role of 5-hydroxymethyl-2-furfural (5-HMF) against hypoxia. Here, we studied the mechanism by using oxygen-dependent degradation domain (ODD)-Luc mice, which are a useful model to probe t...
-
Article
Efficient Gene Transfer into Neonatal Mouse Brain Using Electroporation
In vivo electroporation works as an effective method to transfer exogenous genes into postnatal rodent forebrain. Nevertheless, two deficiencies were found in the reported methods. First, surgical operation br...
-
Article
The protective role of 5-hydroxymethyl-2-furfural (5-HMF) against acute hypobaric hypoxia
Our previous study showed that pretreatment with 5-hydroxymethyl-2-furfural (5-HMF) led to protection against hypoxic injury via a p-ERK-mediated pathway in vitro. Whether the protection of 5-HMF against hypox...
-
Article
The protective role of 5-HMF against hypoxic injury
In an attempt to find new types of anti-hypoxic agents from herbs, we identified 5-hydroxymethyl-2-furfural (5-HMF) as a natural agent that fulfills the criterion. 5-HMF, the final product of carbohydrate meta...
-
Article
Small ncRNA Expression and Regulation Under Hypoxia in Neural Progenitor Cells
Small non-coding RNA (ncRNA) plays critical roles in a large number of cellular processes, including neural development, cell survival and cell determination. Our previous work showed that low oxygen promoted ...
-
Article
The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells
It has been demonstrated that hypoxic preconditioning (HP) enhances the survival ability of the organism against the subsequent acute anoxia (AA). However, it is not yet clear whether necrosis induced by AA ca...
-
Article
Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain
It has been shown that induction of HSP70 by administration of geranylgeranylacetone (GGA) leads to protection against ischemia/reperfusion injury. The present study was performed to determine the effect of GG...
-
Article
Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells
Hypoxia may regulate the proliferation of diverse stem cells. Our previous study showed that hypoxia promoted the proliferation of embryonic neural stem/progenitor cells (NPCs) and that hypoxia inducible facto...
-
Article
The Role of Hypoxia in the Differentiation of P19 Embryonal Carcinoma Cells into Dopaminergic Neurons
Nervous system development at early stage is in hypoxic environment. Very little is known about the role of hypoxia in neuronal development. P19 embryonal carcinoma (EC) cells are a widely used model for study...
-
Article
Effects of hypoxia on the proliferation and differentiation of NSCs
Oxygen is vital to nearly all forms of life on Earth via its role in energy homeostasis and other cell functions. Until recently, the effects of oxygen on the proliferation and differentiation of neural stem c...
