1,196 Result(s)

Article

Erratum: Structure of the adenylyl cyclase catalytic core

Nature 386, 247–253 (1997) In Fig. 3, the sequence in line 2 from 908 to 943 should read PGELVHMLNELFGKFDQIAKENEC…MRIKILGDC, and from 1,004 to 1,022 should be NVLCGVIGLQKWQYDVWSH. An extraneous 19 amino acids ...

Gongyi Zhang, Yu Liu, Arnold E. Ruoho, James H. Hurley in Nature (1997)

Article

Characterization of rtSH3p13 gene encoding a development protein involved in vesicular traffic in spermiogenesis

A cDNA, designated as rtSH3p13, was isolated from a rat testis cDNA library. It consists of 1463 bp nuclear acids, which encodes a protein of 312 amino acids and was assigned the GenBank accession number ...

Yuan QIAO, Ju **ang YANG, **ao Dong ZHANG, Yu LIU, Jian Chao ZHANG… in Cell Research (2004)

Article

Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways

Gap junctions, consisting of connexins, allow the exchange of small molecules (<1 kD) between adjacent cells, thus providing a mechanism for synchronizing the responses of groups of cells to environmental stim...

Li Qiang HE, Fang CAI, Yu LIU, Mu Jun LIU, Zhi ** TAN, Qian PAN… in Cell Research (2005)

Article

Linkage and association analyses of microsatellites and single-nucleotide polymorphisms in nuclear families

Several simulation studies have suggested that a high-density single-nucleotide polymorphisms (SNPs) marker set may be as useful as a traditional microsatellites (MS) marker set in performing whole-genome link...

Jennifer Lin, Kuang-Yu Liu in BMC Genetics (2005)

Article

Boosting alternating decision trees modeling of disease trait information

We applied the alternating decision trees (ADTrees) method to the last 3 replicates from the Aipotu, Danacca, Karangar, and NYC populations in the Problem 2 simulated Genetic Analysis Workshop dataset. Using i...

Kuang-Yu Liu, Jennifer Lin, **aobo Zhou, Stephen TC Wong in BMC Genetics (2005)

Article

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

The development of drug addiction involves a transition from recreational use to compulsive drug seeking and taking, and this progression can occur rapidly with cocaine use. These data highlight the importance...

Drake Morgan, Yu Liu, David C S Roberts in Neuropsychopharmacology (2006)

Article

A novel heterozygous mutation in the Indian hedgehog gene (IHH) is associated with brachydactyly type A1 in a Chinese family

Brachydactyly type A1 (BDA1) is caused by mutations in the Indian hedgehog gene, IHH, on chromosome 2q35-36. In this study, a large five-generation Chinese family with BDA1 was identified and characterized. All a...

Mugen Liu, Xu Wang, Zhou Cai, Zhaohui Tang, Kangsheng Cao… in Journal of Human Genetics (2006)

Article

A novel de novo frame-shift mutation of the EDA gene in a Chinese Han family with hypohidrotic ectodermal dysplasia

Hypohidrotic ectodermal dysplasia (HED) is characterized by severe hypohidrosis, hypotrichosis, and hypodontia. It can be inherited in autosomal dominant, autosomal recessive, or X-linked patterns. Mutations i...

Changzheng Huang, Qinbo Yang, Tie Ke, Haisheng Wang, Xu Wang… in Journal of Human Genetics (2006)

Article

Identification of human dopamine receptors agonists from Chinese herbs

To find human dopamine receptors, especially D1-like receptor specific agonists from Chinese herbs as potential antihypertension drug leads.

Yi-lin Zhang, Hai-qing Zhang, **ao-yu Liu, Shi-neng Hua… in Acta Pharmacologica Sinica (2007)

Article

Identification of a novel GPR143 mutation in a large Chinese family with congenital nystagmus as the most prominent and consistent manifestation

Congenital nystagmus is characterized by involuntary, rhythmical, repeated oscillations of one or both eyes. We studied a large Chinese family with nystagmus as a prominent and consistent manifestation phenoty...

**g Yu Liu, **ang Ren, **ufeng Yang, Tangying Guo, Qi Yao… in Journal of Human Genetics (2007)

Article

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...

L Adrienne Cupples, Heather T Arruda, Emelia J Benjamin… in BMC Medical Genetics (2007)

Article

Identification of chronic myocardial infarction with extracellular or intravascular contrast agents in magnetic resonance imaging

To determine whether extracellular or intravascular contrast agents could detect chronic scarred myocardium in magnetic resonance imaging (MRI).

Jian Wang, Hong-yu Liu, Hang Lü, Bo **ang, Marco Gruwel… in Acta Pharmacologica Sinica (2008)

Article

Identification of a novel KCNQ1 mutation associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long QT syndrome in a Chinese family

Long QT syndrome (LQTS) is a cardiac disorder characterized by prolonged QT intervals on electrocardiograms (ECG), ventricular arrhythmias, and sudden death. Clinically, two inherited forms of LQTS have been d...

Su Zhang, Ke Yin, **ang Ren, Pengyun Wang, Shirong Zhang… in BMC Medical Genetics (2008)

Article

Comparison of the immunogenicities of HIV-1 mutants based on structural modification of env

Eleven env mutants were designed and generated by site-directed mutagenesis of the regions around NAb epitopes and deletions of variable regions in env. The immunogenicities of the generated mutants were evaluate...

Jian-hui Nie, Chun-tao Zhang, Hui-hui Chong, Xue-ling Wu, Chun-yu Liu… in Virologica Sinica (2008)

Article

Application of IPv6 and NGN to the information network of earthquake preparedness and disaster mitigation

Wei-** Lian 连尉**, Ju Liu 刘 举, Yan-yan Hou 侯燕燕, **ao-yu Liu 刘小雨… in Acta Seismologica Sinica (2008)

Article

The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant

The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia....

Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang **ng… in Molecular Pain (2008)

Article

Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: A population based case-control study

Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary r...

Chen-yu Liu, Yi-Hsiang Hsu, Ming-Tsang Wu, Pi-Chen Pan, Chi-Kung Ho, Li Su… in BMC Cancer (2009)

Article

RhoGDIβ-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK

We found that overexpression of RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and suppressed cell cycle progression in a cultured cardiomyoblast cell line. Knockdown of RhoGDIβ express...

Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao… in Journal of Biomedical Science (2009)

Article

Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells

BAG-1 is a multifunctional anti-apoptotic gene with four isoforms, and different BAG-1 isoforms have different anti-apoptotic functions. In this study, we transfected BAG-1 isoforms into the human breast cance...

Hong-yu Liu, Zhuo-min Wang, Yun Bai, Min Wang, Ying Li… in Acta Pharmacologica Sinica (2009)

Article

Osteogenic effects of D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats

Previous studies have shown that D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) has anabolic effects on prednisone (GC)-induced osteoporosis in rats. The current study aims to investigate the molec...

Liao Cui, Yu-yu Liu, Tie Wu, Chun-mei Ai, Huai-qing Chen in Acta Pharmacologica Sinica (2009)