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Article
Open AccessMarked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation
Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells and severe mucosal atrophy. We aimed to explore the distinctive gene ex...
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Article
The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa
Gastric cancer risk can be accurately predicted by measuring the methylation level of a single marker gene in gastric mucosa. However, the mechanism is still uncertain. We hypothesized that the methylation lev...
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Article
HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity
HER2-positive breast cancer has a high chance of achieving pathological complete response when HSD17B4, responsible for peroxisomal β-oxidation of very long-chain fatty acids (VLCFA) and estradiol, is methylation...
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Protocol
DNA Methylation Analysis
DNA methylation of promoter CpG islands silences their downstream genes, and enhancer methylation can be associated with decreased or increased gene expression. DNA methylation alterations in normal and diseas...
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Article
Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation
Prediction of tissue origin of esophagogastric junction (EGJ) adenocarcinomas can be important for therapeutic decision, but no molecular marker is available. Here, we aimed to develop such a marker taking adv...
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Article
Autoimmune gastritis induces aberrant DNA methylation reflecting its carcinogenic potential
Autoimmune gastritis (AIG) is a chronic inflammatory condition in gastric mucosa and is associated with increased cancer risk, though not as high as that by Helicobacter pylori (H. pylori)-associated gastritis (H...
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Article
Open AccessMulti-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy
HER2-positive breast cancers that achieve pathological complete response (pCR) after HER2-directed therapy consistently have good survival. We previously identified HSD17B4 methylation as a marker for pCR by meth...
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Article
Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats
Glucocorticoid (GC)-induced osteoporosis (GIO) is characterized by impaired bone formation, which can be alleviated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. In this study we...
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Article
Progress in fluorene-based wide-bandgap steric semiconductors
Molecular bulks are favorable for the thermal and morphological stability in organic wide-bandgap semiconducting polymers with potential applications in both information and energy electronics. In this review,...
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Article
Advancing and receding wetting behavior of a droplet on a narrow rectangular plane
The contact angle (CA) measurements are generally performed on a large planar surface of a specific substrate with the width larger than the droplet size. In this study, the contact angle hysteresis on a narro...
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Article
Asymptotics for Turbulent Flame Speeds of the Viscous G-Equation Enhanced by Cellular and Shear Flows
G-equations are well-known front propagation models in turbulent combustion which describe the front motion law in the form of local normal velocity equal to a constant (laminar speed) plus the normal projecti...
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Article
Captopril improves osteopenia in ovariectomized rats and promotes bone formation in osteoblasts
The present study was designed to investigate the effects of captopril, an angiotensin-converting enzyme inhibitor (ACEI), on bone loss in aged ovariectomized (OVX) rats and its impact on the differentiation o...
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Article
Osteogenic effects of D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats
Previous studies have shown that D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) has anabolic effects on prednisone (GC)-induced osteoporosis in rats. The current study aims to investigate the molec...
