388 Result(s)
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Article
**g Yu Liu
Biomedicine
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Article
Corynebacterium parvum and metastatic breast cancer
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Beta-Cyclodextrin/Steroid Complexation: Effect of Steroid Structure on Association Equilibria
Molecular associations of beta-cyclodextrin (beta-CyD) with four steroids (cortisone, hydrocortisone, progesterone, and testosterone) have been studied using phase-solubility and spectroscopic techniques. Phas...
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Insulin Aggregation in Aqueous Media and Its Effect on Alpha-Chymotrypsin-Mediated Proteolytic Degradation
Self-association of zinc–insulin monomers into dimers and hexamers may lead to enhanced protection of the peptide from proteolytic degradation. The present study has been undertaken to investigate the relation...
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Cyclodextrin/Weak-Electrolyte Complexation: Interpretation and Estimation of Association Constants from Phase Solubility Diagrams
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Pulmonary Delivery of Free and Liposomal Insulin
The effects of oligomerization and liposomal entrapment on pulmonary insulin absorption were investigated in rats using an intratracheal instillation method. The results indicated that both dimeric and hexamer...
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Pharmacodynamic Analysis of Analgesic Clinical Trials Using Empirical Methods
Data from analgesic clinical trials have characteristics such as ordered categorical longitudinal responses with repeated measures, delay of effect with respect to analgesic plasma concentration, and right-han...
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Pharmacokinetics of Oral Extended-Release Dosage Forms. I. Release Kinetics, Concentration, and Absorbed Fraction
In this study, we derive pharmacokinetic models for oral extended-release (OER) drug products with defined in vivo release kinetics (IVRK) and a compartmental system. Fitting the model to clinical data, we wer...
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The presence and effects of mammalian signal molecules in immunocytes of the insect Leucophaea maderae
Opioid peptides activate immunocytes and opiate alkaloids inhibit this activation in the mussel, Mytilus edulis. Here we present evidence that cells of another invertebrate, Leucophaea maderae, can be influenced ...
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In Vitro-In Vivo Relationship of Oral Extended-Release Dosage Forms
Purpose. A method to establish the in vitro-in vivo relationship of oral extended-release products is proposed.
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Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment
Hearing impairment is the most commonly occurring condition that affects the ability of humans to communicate 1 . More than 50%...
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The gene mutated in bare patches and striated mice encodes a novel 3β-hydroxysteroid dehydrogenase
X-linked dominant disorders that are exclusively lethal prenatally in hemizygous males have been described in human and mouse1. None of the genes responsible has been isolated in either species. The bare patches ...
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Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys
The mechanisms of recovery of manual dexterity after unilateral lesion of the sensorimotor cortex in adult primates remain a matter of debate. It has been proposed that the cortical zone adjacent to the lesion...
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Dephosphorylation of Tau Protein by Calcineurin Triturated into Neural Living Cells
Alzheimer disease and related dementia are characterized by the presence of hyperphosphorylated tau aggregated into filaments. The role of tau phosphorylation in the fibrillogenesis has not yet been unraveled....
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The prevalence of connexin 26 (GJB2) mutations in the Chinese population
Mutations in GJB2, encoding gap junction beta 2 protein (connexin 26), are responsible for the commonest form of non-syndromic recessive deafness in many populations. It has been reported recently that the most ...
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Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats
Previous studies have strongly implicated a role for GABAB receptors in modulating the reinforcing effects of cocaine.
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GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
The interleukin 7 receptor α-chain (IL-7Rα) is essential for T cell development in both humans and mice and for B cell development in mice. Whereas the transcription factor PU.1 regulates IL-7Rα expression in ...
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A Model to Induce Low Temperature Trauma for in vitro Astrogliosis Study
Astrogliosis is an inevitable and rapid response of astrocytes to physical, chemical and pathological injuries. To study astrogliosis, we developed a reproducible in vitro model in which low temperature injury to...
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Effects of extended-access self-administration and deprivation on breakpoints maintained by cocaine in rats
Animal models that identify the effects of self-administration histories on subsequent patterns, levels of intake, and other aspects of reinforcement will help clarify the controlling variables of human drug use.
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Neuronal activity in primary motor cortex differs when monkeys perform somatosensory and visually guided wrist movements
This study was designed to investigate how activity patterns of primary motor cortical (MI) neurons change when monkeys perform the same movements guided by somatosensory and/or visual cues. Two adult male rhe...
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Mechanistic Study of the Cellular Interplay of Transport and Metabolism Using the Synthetic Modeling Method
The aims of this study were 1) to demonstrate a new modeling strategy that uses experimental computational models built by the synthetic method and 2) to study the consequences of spatial alignment, or lack th...
